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    Prrc2b proline-rich coiled-coil 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296637, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Prrc2bprovided by RGD
    Official Full Name
    proline-rich coiled-coil 2Bprovided by RGD
    Primary source
    RGD:1595906
    See related
    Ensembl:ENSRNOG00000010217 AllianceGenome:RGD:1595906
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bat2l
    Summary
    Predicted to be involved in cell differentiation. Predicted to act upstream of or within in utero embryonic development. Orthologous to human PRRC2B (proline rich coiled-coil 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 188.6), Kidney (RPKM 173.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3p12
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (35831017..35916854)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15433357..15519105)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11165687..11252401)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase 7 (inactive) Neighboring gene uncharacterized LOC120101521 Neighboring gene uncharacterized LOC103691765 Neighboring gene small nucleolar RNA, C/D box 62A Neighboring gene small nucleolar RNA, C/D box 62B Neighboring gene protein-O-mannosyltransferase 1 Neighboring gene uncharacterized LOC134486071 Neighboring gene uridine-cytidine kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of proline-rich coiled-coil 2B protein in developing rat brains. Mei Q, et al. Neurosci Lett, 2013 Dec 17. PMID 24466597
    2. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein PRRC2B
    Names
    protein BAT2-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134518.1 → NP_001127990.1  protein PRRC2B isoform 2

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      CH474001
      UniProtKB/TrEMBL
      A6JU43
      Conserved Domains (2) summary
      PHA03247
      Location:1227 → 1495
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    2. NM_001371270.3 → NP_001358199.1  protein PRRC2B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D3ZY45
      Related
      ENSRNOP00000013546.7, ENSRNOT00000013546.7
      Conserved Domains (2) summary
      PHA03247
      Location:1916 → 2184
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      35831017..35916854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234005.3 → XP_006234067.1  protein PRRC2B isoform X1

      See identical proteins and their annotated locations for XP_006234067.1

      UniProtKB/TrEMBL
      D3ZY45, D3ZZ51
      Related
      ENSRNOP00000063117.4
      Conserved Domains (2) summary
      PHA03247
      Location:1917 → 2185
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    2. XM_039104756.2 → XP_038960684.1  protein PRRC2B isoform X3

      UniProtKB/TrEMBL
      D3ZY45
      Conserved Domains (2) summary
      pfam09606
      Location:1884 → 2131
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    3. XM_039104755.2 → XP_038960683.1  protein PRRC2B isoform X2

      UniProtKB/TrEMBL
      D3ZY45
      Conserved Domains (2) summary
      PHA03247
      Location:1916 → 2184
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    4. XM_063283492.1 → XP_063139562.1  protein PRRC2B isoform X4

    5. XM_039104757.2 → XP_038960685.1  protein PRRC2B isoform X5

      UniProtKB/TrEMBL
      A0A0G2KAU9
      Related
      ENSRNOP00000075535.2
      Conserved Domains (2) summary
      PHA03247
      Location:1228 → 1496
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    6. XM_039104759.2 → XP_038960687.1  protein PRRC2B isoform X8

      Conserved Domains (2) summary
      PHA03247
      Location:1228 → 1442
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    7. XM_039104758.2 → XP_038960686.1  protein PRRC2B isoform X6

      UniProtKB/TrEMBL
      A6JU43
      Conserved Domains (2) summary
      PHA03247
      Location:1227 → 1495
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    8. XM_063283493.1 → XP_063139563.1  protein PRRC2B isoform X7

    9. XM_039104754.2 → XP_038960682.1  protein PRRC2B isoform X1

      UniProtKB/TrEMBL
      D3ZY45, D3ZZ51
      Conserved Domains (2) summary
      PHA03247
      Location:1917 → 2185
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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