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    Zbtb42 zinc finger and BTB domain containing 42 [ Mus musculus (house mouse) ]

    Gene ID: 382639, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Zbtb42provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 42provided by MGI
    Primary source
    MGI:MGI:3644133
    See related
    Ensembl:ENSMUSG00000037638 AllianceGenome:MGI:3644133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5188; EG382639; simiRP58
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ZBTB42 (zinc finger and BTB domain containing 42). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 17.1), colon adult (RPKM 15.5) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 F1; 12 61.2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112645042..112649181)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112678648..112682747)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene thymoma viral proto-oncogene 1 Neighboring gene microRNA 6939 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:113913641-113913750 Neighboring gene predicted gene, 30150 Neighboring gene predicted gene, 30298 Neighboring gene predicted gene, 30238 Neighboring gene predicted gene, 46382 Neighboring gene centrosomal protein 170B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the ZBTB42 gene in humans and mice. Devaney SA, et al. Hum Genet, 2011 Apr. PMID 21193930, Free PMC Article
    2. Co-localization of a novel transcriptional repressor simiRP58 with RP58. Takahashi A, et al. Biochem Biophys Res Commun, 2008 Apr 11. PMID 18262495
    3. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 42
    Names
    protein simiRP58

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100460.1 → NP_001093930.1  zinc finger and BTB domain-containing protein 42

      See identical proteins and their annotated locations for NP_001093930.1

      Status: VALIDATED

      Source sequence(s)
      AC124373
      Consensus CDS
      CCDS49190.1
      UniProtKB/Swiss-Prot
      Q811H0
      Related
      ENSMUSP00000133152.2, ENSMUST00000169593.2
      Conserved Domains (5) summary
      smart00225
      Location:25 → 121
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:334 → 388
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:14 → 114
      BTB; BTB/POZ domain
      pfam13465
      Location:347 → 369
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      112645042..112649181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516052.5 → XP_006516115.1  zinc finger and BTB domain-containing protein 42 isoform X1

      See identical proteins and their annotated locations for XP_006516115.1

      Conserved Domains (5) summary
      PLN02328
      Location:97 → 164
      PLN02328; lysine-specific histone demethylase 1 homolog
      COG5048
      Location:252 → 306
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:252 → 272
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:1 → 47
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam13465
      Location:265 → 287
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q811H0.2 GenPept UniProtKB/Swiss-Prot:Q811H0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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