Gc GC, vitamin D binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gcprovided by RGD
Official Full Name: GC, vitamin D binding proteinprovided by RGD
Primary source: RGD:2667
See related: Ensembl:ENSRNOG00000003119 AllianceGenome:RGD:2667
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DBP; VDB; Vdbp; DBP02
Summary: Enables vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Located in several cellular components, including axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 38784.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (18916255..18951670)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (18632146..18667563)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (20267023..20302577)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of vitamin D-binding protein is associated with changes in insulin production in pancreatic beta-cells exposed to p,p'-DDT and p,p'-DDE.
Title: Upregulation of vitamin D-binding protein is associated with changes in insulin production in pancreatic beta-cells exposed to p,p'-DDT and p,p'-DDE.
upregulated DBP in the cerebrospinal fluid could serve as a specific diagnostic biomarker for the progression of multiple sclerosis.
Title: Vitamin D-binding protein in cerebrospinal fluid is associated with multiple sclerosis progression.
expression of DBP in the rat hypothalamus in multiple locations
Title: Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus.

Submit: New GeneRIF Correction

General gene information

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Markers

D14Arb17 (e-PCR), detects polymorphism
- UniSTS:226595

Gc (e-PCR), detects polymorphism
- UniSTS:143183

D14Wox12 (e-PCR)
- UniSTS:118126

D14Mgh3 (e-PCR)
- UniSTS:119443

Gc (e-PCR), detects polymorphism
- UniSTS:532425

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcidiol binding	IEA Inferred from Electronic Annotation more info
enables calcidiol binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables vitamin D binding	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin D binding	IDA Inferred from Direct Assay more info	PubMed
enables vitamin D binding	IEA Inferred from Electronic Annotation more info
enables vitamin D binding	TAS Traceable Author Statement more info	PubMed
enables vitamin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin D metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vitamin D metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vitamin D-binding protein

Names: gc-globulin; group specific component

NP_036696.2

EC 6.3.1.5

EC 6.4.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012564.3 → NP_036696.2 vitamin D-binding protein precursor

See identical proteins and their annotated locations for NP_036696.2

Status: VALIDATED

Source sequence(s)

BC078891

UniProtKB/Swiss-Prot

P04276

UniProtKB/TrEMBL

A6KKH1, F7FJ08, Q68FY4

Related

ENSRNOP00000004174.2, ENSRNOT00000004174.5

Conserved Domains (2) summary

smart00103
Location:19 → 201

ALBUMIN; serum albumin

pfam09164
Location:405 → 469

VitD-bind_III; Vitamin D binding protein, domain III