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    YPT52 Rab family GTPase YPT52 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853884, updated on 13-Apr-2024

    Summary

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    Gene symbol
    YPT52
    Gene description
    Rab family GTPase YPT52
    Primary source
    SGD:S000001722
    Locus tag
    YKR014C
    See related
    AllianceGenome:SGD:S000001722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity. Involved in several processes, including late endosome to vacuole transport via multivesicular body sorting pathway; multivesicular body assembly; and protein localization to organelle. Located in late endosome. Orthologous to several human genes including RAB5B (RAB5B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (465367..466071, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene chromatin-associated RNAPIII regulator FPT1 Neighboring gene sterol-binding protein Neighboring gene uncharacterized protein Neighboring gene Mic60p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endocytosis is essential for pathogenic development in the corn smut fungus Ustilago maydis. Fuchs U, et al. Plant Cell, 2006 Aug. PMID 16798890, Free PMC Article
    2. Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. Singer-Krüger B, et al. J Cell Biol, 1994 Apr. PMID 8163546, Free PMC Article
    3. Ordering of compartments in the yeast endocytic pathway. Prescianotto-Baschong C, et al. Traffic, 2002 Jan. PMID 11872141
    4. Mapping of Vps21 and HOPS binding sites in Vps8 and effect of binding site mutants on endocytic trafficking. Pawelec A, et al. Eukaryot Cell, 2010 Apr. PMID 20173035, Free PMC Article
    5. Non-SCF-type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt52 function. Liu Y, et al. Mol Biol Cell, 2011 May. PMID 21389113, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Cells lacking both Vps9 and Muk1 closely phenocopy double and triple knock-out strains lacking Rab5 paralogs.
      Title: Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast.
    2. Roy1, regulates cell viability and intracellular trafficking by inhibiting Ypt52, which may provide an explanation for the dormancy of Ypt52.
      Title: Non-SCF-type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt52 function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in multivesicular body assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to endosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in late endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rab family GTPase YPT52
    NP_012939.1
    • Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      465367..466071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179804.1 → NP_012939.1  TPA: Rab family GTPase YPT52 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012939.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX79, P36018
      UniProtKB/TrEMBL
      A0A6A5PXQ5, A6ZZX8, B3LR98, B5VMG1, C7GNP4, C8ZCH9, G2WI45, N1P0G3
      Conserved Domains (1) summary
      cd01860
      Location:3 → 194
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36018.1

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