mrg-1 Mortality factor related protein 1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Gene symbol: mrg-1
Gene description: Mortality factor related protein 1
Primary source: WormBase:WBGene00003406
Locus tag: CELE_Y37D8A.9
See related: AllianceGenome:WB:WBGene00003406
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including chromosome organization; positive regulation of chromosome attachment to the nuclear envelope; and regulation of transcription by RNA polymerase II. Located in autosome and euchromatin. Is expressed in several structures, including AB; C; D; germ cell; and germ line. Orthologous to human MORF4L1 (mortality factor 4 like 1) and MORF4L2 (mortality factor 4 like 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See mrg-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (12871029..12874656, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRG-1 has two distinct functions: chromatin-based transcriptional silencing and preserving genomic integrity at the maintenance stage of primordial germ cells.
Title: MRG-1 is required for both chromatin-based transcriptional silencing and genomic integrity of primordial germ cells in Caenorhabditis elegans.
MRG-1 safeguards germ cells against conversion into neurons.
Title: MRG-1/MRG15 Is a Barrier for Germ Cell to Neuron Reprogramming in Caenorhabditis elegans.
Authors show that this characteristic spatiotemporal expression pattern is dictated by the mrg-1 3'UTR and is differentially regulated at the RNA level between germline and somatic cells
Title: Restricted distribution of mrg-1 mRNA in C. elegans primordial germ cells through germ granule-independent regulation.
Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line.
Title: Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line.
MRG-1 is critical for genomic integrity by promoting meiotic DNA double strand breaks repair and synapsis progression in meiosis.
Title: MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells.
evidence for presynaptic chromosome pairing activity intrinsic to non-pairing center regions, which is facilitated by a conserved chromodomain protein, MRG-1
Title: The chromodomain protein MRG-1 facilitates SC-independent homologous pairing during meiosis in Caenorhabditis elegans.
Here we demonstrate the importance of mrg-1 in development and reproduction in C. elegans and discuss its potential to impact the aging process.
Title: Functional analysis of MRG-1: the ortholog of human MRG15 in Caenorhabditis elegans.
MRG-1 is required to maintain repression in the maternal germ line of transgenes on extrachromosomal arrays, and of several X-linked genes previously shown to depend on MES-4 for repression
Title: MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans.
MRG-1 is required maternally to form normal primordial germ cells with the potential to start mitotic proliferation during post-embryonic development.
Title: MRG-1, a mortality factor-related chromodomain protein, is required maternally for primordial germ cells to initiate mitotic proliferation in C. elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Y37D8A.9 (e-PCR)
- UniSTS:319749

Y37D8A.10 (e-PCR)
- UniSTS:320642

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromosome attachment to the nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization involved in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to euchromatin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in autosome	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Mortality factor related protein 1

NP_001122727.1

Confirmed by transcript evidence

NP_499675.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

12871029..12874656 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067274.6 → NP_499675.1 Mortality factor related protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499675.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XWW2

Conserved Domains (2) summary

pfam05712
Location:125 → 314

MRG

cl28914
Location:19 → 63

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
NM_001129255.6 → NP_001122727.1 Mortality factor related protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122727.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A7DTF0, Q9XWW2

Conserved Domains (2) summary

pfam05712
Location:125 → 316

MRG

cl28914
Location:19 → 63

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains