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    Pamr1 peptidase domain containing associated with muscle regeneration 1 [ Mus musculus (house mouse) ]

    Gene ID: 210622, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pamr1provided by MGI
    Official Full Name
    peptidase domain containing associated with muscle regeneration 1provided by MGI
    Primary source
    MGI:MGI:2445082
    See related
    Ensembl:ENSMUSG00000027188 AllianceGenome:MGI:2445082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ramp; 5930437L24; E430002G05Rik
    Summary
    Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; brain ventricular layer; limb; metanephros; and skeleton. Orthologous to human PAMR1 (peptidase domain containing associated with muscle regeneration 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 20.9), limb E14.5 (RPKM 13.3) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E2; 2 54.13 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (102380325..102473386)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (102549939..102643041)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05252 Neighboring gene predicted gene, 39890 Neighboring gene four jointed box 1 Neighboring gene STARR-seq mESC enhancer starr_05255 Neighboring gene STARR-seq mESC enhancer starr_05256 Neighboring gene STARR-seq mESC enhancer starr_05257 Neighboring gene STARR-seq mESC enhancer starr_05258 Neighboring gene predicted gene, 57687 Neighboring gene solute carrier family 1 (glial high affinity glutamate transporter), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2631 Neighboring gene predicted gene 13872

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The single EGF-like domain of mouse PAMR1 is modified by O-Glucose, O-Fucose and O-GlcNAc. Pennarubia F, et al. Glycobiology, 2021 Jan 9. PMID 32518939
    2. Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients. Nakayama Y, et al. Am J Pathol, 2004 May. PMID 15111323, Free PMC Article
    3. An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes. Sharma PR, et al. Endocrinology, 2015 Sep. PMID 26018251, Free PMC Article
    4. βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function. Arnes L, et al. Genes Dev, 2016 Mar 1. PMID 26944677, Free PMC Article
    5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The single EGF-like domain of mouse PAMR1 is modified by O-Glucose, O-Fucose and O-GlcNAc.
      Title: The single EGF-like domain of mouse PAMR1 is modified by O-Glucose, O-Fucose and O-GlcNAc.
    2. related to islet dysfunction during the development of type 2 diabetes
      Title: An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.
    3. RAMP may play a role in the regeneration of skeletal muscle, and its down-regulation could be involved in the progression of Duchenne muscular dystrophy
      Title: Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inactive serine protease PAMR1
    Names
    peptidase domain-containing protein associated with muscle regeneration 1
    regeneration associated muscle protease
    regeneration-associated muscle protease homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173749.4 → NP_776110.3  inactive serine protease PAMR1 precursor

      See identical proteins and their annotated locations for NP_776110.3

      Status: VALIDATED

      Source sequence(s)
      AA444868, AL844605, BB620582, BY264071, BY266233, CX564812
      Consensus CDS
      CCDS16468.1
      UniProtKB/Swiss-Prot
      A2AQI2, Q8BU25, Q8K2B8
      Related
      ENSMUSP00000028612.8, ENSMUST00000028612.8
      Conserved Domains (5) summary
      cd00033
      Location:280 → 342
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:461 → 715
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:128 → 234
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00054
      Location:240 → 272
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:461 → 718
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      102380325..102473386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160219.1 → XP_036016112.1  inactive serine protease PAMR1 isoform X1

      Conserved Domains (3) summary
      cd00033
      Location:280 → 342
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd00041
      Location:128 → 234
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00054
      Location:240 → 272
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BU25.3 GenPept UniProtKB/Swiss-Prot:Q8BU25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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