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    Ggamma30A G protein gamma subunit 30A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45234, updated on 10-May-2024

    Summary

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    Official Symbol
    Ggamma30Aprovided by FlyBase
    Official Full Name
    G protein gamma subunit 30Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267252
    Locus tag
    Dmel_CG3694
    See related
    AllianceGenome:FB:FBgn0267252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18511; CG3694; CG43733; Dmel\CG3694; G-gamma30A; Galpha30A; Ggamma; Ggammae; Ggamma[[e]]; GNG gene like; G[[gamma30A]]; G[[gamma]]; lincRNA.S701
    Old locus tag
    Dmel_CG43733
    Summary
    Enables protein heterodimerization activity. Involved in G protein-coupled receptor signaling pathway; cellular response to carbon dioxide; and phototransduction. Located in cytoplasm and rhabdomere. Part of heterotrimeric G-protein complex. Is expressed in head and photoreceptor cell. Orthologous to human GNG13 (G protein subunit gamma 13). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    30A7-30A8; 2-35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9256563..9302494)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9256563..9302494)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lectin-30A Neighboring gene long non-coding RNA:CR45262 Neighboring gene borealin-related Neighboring gene long non-coding RNA:CR42844 Neighboring gene long non-coding RNA:CR45456

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. G-protein gamma subunit 1 is required for sugar reception in Drosophila. Ishimoto H, et al. EMBO J, 2005 Sep 21. PMID 16121192, Free PMC Article
    2. Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system. Schillo S, et al. J Biol Chem, 2004 Aug 27. PMID 15205461
    3. G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13). Blake BL, et al. J Biol Chem, 2001 Dec 28. PMID 11675383
    4. A novel Ggamma isolated from Drosophila constitutes a visual G protein gamma subunit of the fly compound eye. Schulz S, et al. J Biol Chem, 1999 Dec 31. PMID 10608815
    5. Selective photostimulation of genetically chARGed neurons. Zemelman BV, et al. Neuron, 2002 Jan 3. PMID 11779476

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ggammae has a role in light sensitivity of the visual system
      Title: Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to carbon dioxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phototransduction IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of heterotrimeric G-protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in rhabdomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G protein gamma subunit 30A
    Names
    CG3694-PA
    CG3694-PB
    CG3694-PC
    CG3694-PF
    CG3694-PG
    CG3694-PH
    CG3694-PI
    CG3694-PJ
    G protein gamma30A
    G protein subunit gamma at 30A
    Ggamma30A-PA
    Ggamma30A-PB
    Ggamma30A-PC
    Ggamma30A-PF
    Ggamma30A-PG
    Ggamma30A-PH
    Ggamma30A-PI
    Ggamma30A-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9256563..9302494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164852.3 → NP_723452.1  G protein gamma subunit 30A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Related
      FBpp0079397
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    2. NM_001169447.2 → NP_001162918.1  G protein gamma subunit 30A, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162918.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    3. NM_001298847.1 → NP_001285776.1  G protein gamma subunit 30A, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDM7
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    4. NM_080068.4 → NP_524807.1  G protein gamma subunit 30A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524807.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Related
      FBpp0079395
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    5. NM_001201820.2 → NP_001188749.1  G protein gamma subunit 30A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188749.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    6. NM_164851.3 → NP_723451.1  G protein gamma subunit 30A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723451.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Related
      FBpp0079396
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    7. NM_001259021.2 → NP_001245950.1  G protein gamma subunit 30A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245950.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
      UniProtKB/TrEMBL
      E1JHC3
      Conserved Domains (1) summary
      cd00068
      Location:11 → 67
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    8. NM_001169446.3 → NP_001162917.2  G protein gamma subunit 30A, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162917.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHC4
      Conserved Domains (1) summary
      cd00068
      Location:3 → 59
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHC3 E1JHC3
    E1JHC4 E1JHC4
    Q9NFZ3.1 Q9NFZ3
    X2JDM7 X2JDM7

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