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    Act88F Actin 88F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41885, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Act88Fprovided by FlyBase
    Official Full Name
    Actin 88Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000047
    Locus tag
    Dmel_CG5178
    See related
    AllianceGenome:FB:FBgn0000047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    act 88F; Act(88F); Act88-F; act88F; Act88f; ACT88F; actin; Actin; Actin88F; ArpD; CG5178; Dmel\CG5178; E; Ifm(3)7; P83967; rsd
    Summary
    Involved in muscle thin filament assembly and skeletal myofibril assembly. Located in Z disc. Is expressed in adult head; spermatozoon; and thorax. Used to study congenital structural myopathy; myopathy; and nemaline myopathy. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome and autosomal dominant nonsyndromic deafness 20. Orthologous to human ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    88F5-88F5; 3-57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15439969..15442177)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11265691..11267899)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45911 Neighboring gene mir-2c stem loop Neighboring gene uncharacterized protein Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif A Neighboring gene snoRNA:Orphan H/ACA box 9 Neighboring gene B9d1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis of IFM-specific actin and myosin nulls in Drosophila melanogaster unravels lesion-specific expression blueprints across muscle mutations. Madan A, et al. Gene, 2017 Oct 5. PMID 28739398
    2. Transplanted wing and leg imaginal discs in Drosophila melanogaster demonstrate interactions between epidermis and myoblasts in muscle formation. Raghavan KV, et al. Dev Genes Evol, 1996 Jun. PMID 24173396
    3. Dominant negative mutant actins identified in flightless Drosophila can be classified into three classes. Noguchi TQ, et al. J Biol Chem, 2010 Feb 12. PMID 19933578, Free PMC Article
    4. Role of calcium in the regulation of mechanical power in insect flight. Gordon S, et al. Proc Natl Acad Sci U S A, 2006 Mar 14. PMID 16537527, Free PMC Article
    5. Molecular characterization of mutant actin genes which induce heat-shock proteins in Drosophila flight muscles. Okamoto H, et al. EMBO J, 1986 Mar. PMID 16453675, Free PMC Article

    See all (273) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate a role for CF2 as a direct negative regulator of the thin filament protein gene Actin 88F.
      Title: CF2 represses Actin 88F gene expression and maintains filament balance during indirect flight muscle development in Drosophila.
    2. Results report on the structure and in situ location of arthrin (monoubiquitinated actin).
      Title: Structural studies of arthrin: monoubiquitinated actin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle thin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle thin filament HDA PubMed 

    General protein information

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    Preferred Names
    actin 88F
    Names
    88F actin
    Act88F-PA
    CG5178-PA
    F-actin
    actin
    actin88F
    arthrin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15439969..15442177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079643.2 → NP_524367.1  actin 88F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524367.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83967
      UniProtKB/TrEMBL
      B6IDW7, C6TP14
      Related
      FBpp0082597
      Conserved Domains (1) summary
      PTZ00281
      Location:1 → 376
      PTZ00281; actin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83967.1 P83967

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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