DOCK8 dedicator of cytokinesis 8 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: DOCK8provided by VGNC
Official Full Name: dedicator of cytokinesis 8provided by VGNC
Primary source: VGNC:VGNC:40052
See related: Ensembl:ENSCAFG00845001647
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 51

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (89701521..89930127)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (89621978..89850471)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (89820804..90055669)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (89347665..89576215)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (89059801..89288656)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of establishment of T cell polarity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell leading edge	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dedicator of cytokinesis protein 8; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051805.1 Reference ROS_Cfam_1.0

Range

89701521..89930127

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038655262.1 → XP_038511190.1 dedicator of cytokinesis protein 8 isoform X1

UniProtKB/TrEMBL

A0A8C0LN09, A0A8C0N5V5, A0A8I3MME8

Related

ENSCAFP00845002298.1, ENSCAFT00845002883.1

Conserved Domains (3) summary

cd08696
Location:559 → 739

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1638 → 2059

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:56 → 166

DUF3398; Domain of unknown function (DUF3398)
XM_038655263.1 → XP_038511191.1 dedicator of cytokinesis protein 8 isoform X2

UniProtKB/TrEMBL

A0A8C0Q2V3, A0A8I3MJQ9

Related

ENSCAFP00845002373.1, ENSCAFT00845002978.1

Conserved Domains (3) summary

cd08696
Location:491 → 671

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1570 → 1991

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:1 → 98

DUF3398; Domain of unknown function (DUF3398)
XM_038655264.1 → XP_038511192.1 dedicator of cytokinesis protein 8 isoform X2

UniProtKB/TrEMBL

A0A8C0Q2V3, A0A8I3MJQ9

Conserved Domains (3) summary

cd08696
Location:491 → 671

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1570 → 1991

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:1 → 98

DUF3398; Domain of unknown function (DUF3398)
XM_038655265.1 → XP_038511193.1 dedicator of cytokinesis protein 8 isoform X3

UniProtKB/TrEMBL

A0A8C0R8M3

Conserved Domains (2) summary

cd08696
Location:194 → 374

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1273 → 1694

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

Alternate UMICH_Zoey_3.1

Genomic

NC_049261.1 Alternate UMICH_Zoey_3.1

Range

89347665..89576215

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038466454.1 → XP_038322382.1 dedicator of cytokinesis protein 8 isoform X1

Conserved Domains (3) summary

cd08696
Location:559 → 739

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1638 → 2059

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:56 → 166

DUF3398; Domain of unknown function (DUF3398)
XM_038466455.1 → XP_038322383.1 dedicator of cytokinesis protein 8 isoform X2

Conserved Domains (3) summary

cd08696
Location:491 → 671

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1570 → 1991

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:1 → 98

DUF3398; Domain of unknown function (DUF3398)
XM_038466456.1 → XP_038322384.1 dedicator of cytokinesis protein 8 isoform X2

Conserved Domains (3) summary

cd08696
Location:491 → 671

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1570 → 1991

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:1 → 98

DUF3398; Domain of unknown function (DUF3398)
XM_038466457.1 → XP_038322385.1 dedicator of cytokinesis protein 8 isoform X3

Conserved Domains (2) summary

cd08696
Location:194 → 374

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1273 → 1694

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049742.1 Alternate UNSW_CanFamBas_1.0

Range

89059801..89288656

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038591460.1 → XP_038447388.1 dedicator of cytokinesis protein 8 isoform X1

Conserved Domains (3) summary

cd08696
Location:559 → 739

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1638 → 2059

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:56 → 166

DUF3398; Domain of unknown function (DUF3398)
XM_038591461.1 → XP_038447389.1 dedicator of cytokinesis protein 8 isoform X2

Conserved Domains (3) summary

cd08696
Location:491 → 671

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1570 → 1991

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:1 → 98

DUF3398; Domain of unknown function (DUF3398)
XM_038591462.1 → XP_038447390.1 dedicator of cytokinesis protein 8 isoform X2

Conserved Domains (3) summary

cd08696
Location:491 → 671

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1570 → 1991

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:1 → 98

DUF3398; Domain of unknown function (DUF3398)
XM_038591463.1 → XP_038447391.1 dedicator of cytokinesis protein 8 isoform X3

Conserved Domains (2) summary

cd08696
Location:194 → 374

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1273 → 1694

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049222.1 Alternate UU_Cfam_GSD_1.0

Range

89820804..90055669

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038527147.1 → XP_038383075.1 LOW QUALITY PROTEIN: dedicator of cytokinesis protein 8 isoform X1

UniProtKB/TrEMBL

A0A8C0LN09, A0A8C0N5V5, A0A8I3MME8

Conserved Domains (3) summary

cd08696
Location:559 → 739

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1638 → 2059

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:56 → 166

DUF3398; Domain of unknown function (DUF3398)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

89621978..89850471

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038590975.1 → XP_038446903.1 dedicator of cytokinesis protein 8 isoform X1

UniProtKB/TrEMBL

A0A8P0P0E7, A0A8P0P9W7

Conserved Domains (3) summary

cd08696
Location:559 → 739

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1638 → 2059

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:56 → 166

DUF3398; Domain of unknown function (DUF3398)
XM_005615889.4 → XP_005615946.1 dedicator of cytokinesis protein 8 isoform X2

See identical proteins and their annotated locations for XP_005615946.1

UniProtKB/TrEMBL

A0A8P0SZC1

Conserved Domains (3) summary

cd08696
Location:491 → 671

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1570 → 1991

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:5 → 96

DUF3398; Domain of unknown function (DUF3398)
XM_533535.7 → XP_533535.4 dedicator of cytokinesis protein 8 isoform X2

See identical proteins and their annotated locations for XP_533535.4

UniProtKB/TrEMBL

A0A8P0SZC1

Conserved Domains (3) summary

cd08696
Location:491 → 671

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1570 → 1991

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

pfam11878
Location:5 → 96

DUF3398; Domain of unknown function (DUF3398)
XM_022421527.2 → XP_022277235.1 dedicator of cytokinesis protein 8 isoform X3

UniProtKB/TrEMBL

A0A8C0R8M3

Conserved Domains (2) summary

cd08696
Location:194 → 374

C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11701
Location:1273 → 1694

DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8