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    SLC38A10 solute carrier family 38 member 10 [ Homo sapiens (human) ]

    Gene ID: 124565, updated on 11-Apr-2024

    Summary

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    Official Symbol
    SLC38A10provided by HGNC
    Official Full Name
    solute carrier family 38 member 10provided by HGNC
    Primary source
    HGNC:HGNC:28237
    See related
    Ensembl:ENSG00000157637 MIM:616525; AllianceGenome:HGNC:28237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP1744; SNAT10
    Summary
    Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to act upstream of or within bone development. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen (RPKM 17.0), placenta (RPKM 15.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    17q25.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81244811..81295307, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82153934..82207205, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79218611..79269107, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904081 Neighboring gene TEPSIN adaptor related protein complex 4 accessory protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79212179-79212761 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79212737-79212952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12956 Neighboring gene Sharpr-MPRA regulatory region 11657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12957 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79225481-79226148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79228507-79229198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79255689-79256202 Neighboring gene Sharpr-MPRA regulatory region 13761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12961 Neighboring gene uncharacterized LOC124904082 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79273333-79273505 Neighboring gene CRISPRi-validated cis-regulatory element chr17.5937 Neighboring gene long intergenic non-protein coding RNA 482

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease. Hashimoto M, et al. J Alzheimers Dis, 2019. PMID 31524172
    2. The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission. Hellsten SV, et al. FEBS Open Bio, 2017 Jun. PMID 28593130, Free PMC Article
    3. The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38. Sundberg BE, et al. J Mol Neurosci, 2008 Jun. PMID 18418736
    4. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Schiöth HB, et al. Mol Aspects Med, 2013 Apr-Jun. PMID 23506890
    5. Joint influence of small-effect genetic variants on human longevity. Yashin AI, et al. Aging (Albany NY), 2010 Sep. PMID 20834067, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease.
      Title: A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Joint influence of small-effect genetic variants on human longevity.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35718, FLJ46399, MGC15523

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 38 member 10; putative sodium-coupled neutral amino acid transporter 10
    Names
    Sodium-coupled neutral amino acid transporter 10
    amino acid transporter SLC38A10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037984.3 → NP_001033073.1  solute carrier family 38 member 10 isoform a

      See identical proteins and their annotated locations for NP_001033073.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK128330, BC014642, BI194553, BM129331, BQ642219, BU552914, CA447446, HY036951
      Consensus CDS
      CCDS42397.1
      UniProtKB/Swiss-Prot
      Q6ZRC5, Q8NA99, Q96C66, Q9HBR0
      Related
      ENSP00000363891.3, ENST00000374759.8
      Conserved Domains (4) summary
      PHA00666
      Location:582 → 739
      PHA00666; putative protease
      COG0814
      Location:14 → 397
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam05466
      Location:481 → 683
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_138570.4 → NP_612637.1  solute carrier family 38 member 10 isoform b

      See identical proteins and their annotated locations for NP_612637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BC014642, BQ642219, CA416101, HY036951
      Consensus CDS
      CCDS11780.1
      UniProtKB/Swiss-Prot
      Q9HBR0
      Related
      ENSP00000288439.5, ENST00000288439.9
      Conserved Domains (3) summary
      COG0814
      Location:14 → 397
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam05466
      Location:481 → 683
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      81244811..81295307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257019.2 → XP_005257076.1  putative sodium-coupled neutral amino acid transporter 10 isoform X2

      Conserved Domains (3) summary
      COG0814
      Location:14 → 397
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam05466
      Location:481 → 683
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_011524289.2 → XP_011522591.1  putative sodium-coupled neutral amino acid transporter 10 isoform X3

      Conserved Domains (4) summary
      PHA00666
      Location:589 → 746
      PHA00666; putative protease
      COG0814
      Location:14 → 404
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam05466
      Location:488 → 690
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00456
      Location:6 → 388
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_011524288.2 → XP_011522590.1  putative sodium-coupled neutral amino acid transporter 10 isoform X1

      Conserved Domains (3) summary
      COG0814
      Location:14 → 404
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam05466
      Location:488 → 690
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00456
      Location:6 → 388
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. XM_011524290.2 → XP_011522592.1  putative sodium-coupled neutral amino acid transporter 10 isoform X4

      Conserved Domains (2) summary
      PRK07764
      Location:449 → 886
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl00456
      Location:2 → 299
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82153934..82207205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314988.1 → XP_054170963.1  putative sodium-coupled neutral amino acid transporter 10 isoform X2

    2. XM_054314989.1 → XP_054170964.1  putative sodium-coupled neutral amino acid transporter 10 isoform X3

    3. XM_054314987.1 → XP_054170962.1  putative sodium-coupled neutral amino acid transporter 10 isoform X1

    4. XM_054314990.1 → XP_054170965.1  putative sodium-coupled neutral amino acid transporter 10 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HBR0.2 GenPept UniProtKB/Swiss-Prot:Q9HBR0

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