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    cnc cap-n-collar [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42743, updated on 27-Mar-2024

    Summary

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    Official Symbol
    cncprovided by FlyBase
    Official Full Name
    cap-n-collarprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262975
    Locus tag
    Dmel_CG43286
    See related
    AllianceGenome:FB:FBgn0262975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5134; anon-WO0153538.6; anon-WO0153538.7; BcDNA:RE05559; CG13826; CG17894; CG43286; CG4566; CG4578; Cnc; CnC; CNC; cnc-C; Cnc-C; cnc14; cncc; cncC; Cncc; CncC; CnCC; cncC/Nrf2; CNC_DROME; DM12; Dmel\CG43286; dNrf2; l(3)03921; l(3)j5E7; NRF; nrf2; Nrf2; NRF2
    Old locus tag
    Dmel_CG13826; Dmel_CG17894
    Summary
    Enables protein heterodimerization activity. Contributes to DNA-binding transcription factor activity. Involved in several processes, including intestinal stem cell homeostasis; oocyte axis specification; and regulation of intracellular mRNA localization. Located in nucleus and polytene chromosome puff. Is expressed in several structures, including ectoderm; ectoderm anlage; epithelium; head segment; and presumptive embryonic/larval digestive system. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to several human genes including NFE2L1 (NFE2 like bZIP transcription factor 1) and NFE2L2 (NFE2 like bZIP transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    94E4-94E7; 3-78 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23185580..23226711, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19011302..19052433, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase AC39 subunit 2 Neighboring gene uncharacterized protein Neighboring gene Inwardly rectifying potassium channel 1 Neighboring gene uncharacterized protein Neighboring gene fuzzy onions Neighboring gene uncharacterized protein Neighboring gene Rad60

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease models via induction of Nrf2. Qiao J, et al. Mol Med Rep, 2022 Jun. PMID 35543148, Free PMC Article
    2. An enriched polyphenolic extract obtained from the by-product of Rosa damascena hydrodistillation activates antioxidant and proteostatic modules. Dina E, et al. Phytomedicine, 2021 Dec. PMID 34619431
    3. Cruciferous vegetables (Brassica oleracea) confer cytoprotective effects in Drosophila intestines. Lyles JT, et al. Gut Microbes, 2021 Jan-Dec. PMID 33966605, Free PMC Article
    4. Possible involvement of transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effect of caffeic acid on paraquat-induced oxidative damage in Drosophila melanogaster. Dos Santos Nunes RG, et al. Pestic Biochem Physiol, 2019 Jun. PMID 31153464
    5. Cap-n-Collar Promotes Tissue Regeneration by Regulating ROS and JNK Signaling in the Drosophila melanogaster Wing Imaginal Disc. Brock AR, et al. Genetics, 2017 Jul. PMID 28512185, Free PMC Article

    See all (314) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interplay between autophagy and CncC regulates dendrite pruning in Drosophila.
      Title: Interplay between autophagy and CncC regulates dendrite pruning in Drosophila.
    2. Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling.
      Title: Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling.
    3. Determination of Complex Formation between Drosophila Nrf2 and GATA4 Factors at Selective Chromatin Loci Demonstrates Transcription Coactivation.
      Title: Determination of Complex Formation between Drosophila Nrf2 and GATA4 Factors at Selective Chromatin Loci Demonstrates Transcription Coactivation.
    4. Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status.
      Title: Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status.
    5. Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models.
      Title: Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models.
    6. Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes.
      Title: Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes.
    7. Preserving transcriptional stress responses as an anti-aging strategy.
      Title: Preserving transcriptional stress responses as an anti-aging strategy.
    8. Mutations in genes cnc or dKeap1 modulate stress resistance and metabolic processes in Drosophila melanogaster.
      Title: Mutations in genes cnc or dKeap1 modulate stress resistance and metabolic processes in Drosophila melanogaster.
    9. increased expression of nuclear factor erythroid 2-related factor (Nrf2) in Drosophila activated cytoprotective modules and enhanced stress tolerance.
      Title: Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.
    10. Study shows that Drosophila CncC links cell cycle control with proteostatic responses in intestinal stem cells via the accumulation of dacapo, a p21 cell cycle inhibitor homologue, as well as the transcriptional activation of genes encoding proteases and proteasome subunits.
      Title: Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blastoderm segmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton polarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte nucleus localization involved in oocyte dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of bicoid mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cap-n-collar
    Names
    CG43286-PA
    CG43286-PB
    CG43286-PC
    CG43286-PD
    CG43286-PE
    CG43286-PF
    CG43286-PG
    CG43286-PH
    CG43286-PI
    CG43286-PJ
    CG43286-PK
    CG43286-PL
    CG43286-PM
    CG43286-PN
    CG43286-PO
    CG43286-PP
    Cap 'n' collar
    Cap'n'collar
    Cap'n'collar B
    Cap-and-collar
    Cap-n-colar
    Cap-n-collar
    cap and collar
    cap n collar
    cnc-PA
    cnc-PB
    cnc-PC
    cnc-PD
    cnc-PE
    cnc-PF
    cnc-PG
    cnc-PH
    cnc-PI
    cnc-PJ
    cnc-PK
    cnc-PL
    cnc-PM
    cnc-PN
    cnc-PO
    cnc-PP
    nuclear factor E2-related factor 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23185580..23226711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170053.3 → NP_732833.1  cap-n-collar, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732833.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V398, C7LAC2, O96506, P20482, Q1WWD8, Q9TZS3, Q9VCP6, Q9VCP8, Q9VCP9
      UniProtKB/TrEMBL
      A0A0B4K6E1
      Related
      FBpp0297671
      Conserved Domains (1) summary
      cd14698
      Location:1192 → 1259
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    2. NM_001275935.1 → NP_001262864.1  cap-n-collar, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHP5
      Conserved Domains (1) summary
      cd14698
      Location:1192 → 1259
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    3. NM_001260331.1 → NP_001247260.1  cap-n-collar, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247260.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V398, C7LAC2, O96506, P20482, Q1WWD8, Q9TZS3, Q9VCP6, Q9VCP8, Q9VCP9
      UniProtKB/TrEMBL
      A0A0B4K6E1
      Conserved Domains (1) summary
      cd14698
      Location:1192 → 1259
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    4. NM_001260330.1 → NP_001247259.1  cap-n-collar, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247259.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V398, C7LAC2, O96506, P20482, Q1WWD8, Q9TZS3, Q9VCP6, Q9VCP8, Q9VCP9
      UniProtKB/TrEMBL
      A0A0B4K6E1
      Conserved Domains (1) summary
      cd14698
      Location:1192 → 1259
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    5. NM_170058.2 → NP_732838.2  cap-n-collar, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732838.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20482
      Conserved Domains (1) summary
      cd14698
      Location:855 → 922
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    6. NM_170054.4 → NP_732834.1  cap-n-collar, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732834.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20482
      Related
      FBpp0297672
      Conserved Domains (1) summary
      cd14698
      Location:614 → 681
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    7. NM_001275936.1 → NP_001262865.1  cap-n-collar, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262865.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGT0
      Conserved Domains (1) summary
      cd14698
      Location:520 → 587
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    8. NM_170059.3 → NP_732839.1  cap-n-collar, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732839.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6G8
      Related
      FBpp0297673
      Conserved Domains (1) summary
      cd14698
      Location:342 → 409
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    9. NM_001260327.2 → NP_001247256.1  cap-n-collar, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247256.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6G8
      Conserved Domains (1) summary
      cd14698
      Location:342 → 409
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    10. NM_170057.2 → NP_732837.1  cap-n-collar, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732837.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6G8
      Related
      FBpp0297668
      Conserved Domains (1) summary
      cd14698
      Location:342 → 409
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    11. NM_001260328.1 → NP_001247257.1  cap-n-collar, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247257.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6G8
      Conserved Domains (1) summary
      cd14698
      Location:342 → 409
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    12. NM_170056.2 → NP_732836.1  cap-n-collar, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732836.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6G8
      Related
      FBpp0297669
      Conserved Domains (1) summary
      cd14698
      Location:342 → 409
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    13. NM_170055.2 → NP_732835.1  cap-n-collar, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732835.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6G8
      Related
      FBpp0297670
      Conserved Domains (1) summary
      cd14698
      Location:342 → 409
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    14. NM_001260332.2 → NP_001247261.1  cap-n-collar, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6Z0
      Conserved Domains (1) summary
      cd14698
      Location:942 → 1009
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    15. NM_001260333.2 → NP_001247262.1  cap-n-collar, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247262.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6Z0
      Conserved Domains (1) summary
      cd14698
      Location:942 → 1009
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain

    16. NM_001260329.2 → NP_001247258.1  cap-n-collar, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247258.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6Z0
      Conserved Domains (1) summary
      cd14698
      Location:942 → 1009
      bZIP_CNC; Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6E1 A0A0B4K6E1
    A0A0B4K6G8 A0A0B4K6G8
    A0A0B4K6Z0 A0A0B4K6Z0
    A0A0B4KGT0 A0A0B4KGT0
    A0A0B4KHP5 A0A0B4KHP5
    P20482.3 P20482
    Q9VCP5 Q9VCP5

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