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    Abhd14a abhydrolase domain containing 14A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300982, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Abhd14aprovided by RGD
    Official Full Name
    abhydrolase domain containing 14Aprovided by RGD
    Primary source
    RGD:1309721
    See related
    Ensembl:ENSRNOG00000011936 AllianceGenome:RGD:1309721
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dorz1; RGD1309721
    Summary
    Predicted to enable hydrolase activity. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Orthologous to human ABHD14A (abhydrolase domain containing 14A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 122.8), Adrenal (RPKM 31.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115957853..115965697, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107079139..107089004, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115141575..115151222, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene uncharacterized LOC134480228 Neighboring gene dual specificity phosphatase 7 Neighboring gene abhydrolase domain containing 14b Neighboring gene aminoacylase 1 Neighboring gene poly(rC) binding protein 4 Neighboring gene G protein-coupled receptor 62

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse. Hoshino J, et al. Brain Res Mol Brain Res, 2003 Dec 12. PMID 14667578
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95137

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein ABHD14A
    Names
    abhydrolase domain-containing protein 14A
    alpha/beta hydrolase domain-containing protein 14A
    down-regulated in Zic1 deficient cerebellar primordium

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009670.1 → NP_001009670.1  protein ABHD14A

      See identical proteins and their annotated locations for NP_001009670.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088472
      UniProtKB/Swiss-Prot
      Q5I0C4
      UniProtKB/TrEMBL
      A0A8L2Q7K3, A6I2R8
      Related
      ENSRNOP00000016056.7, ENSRNOT00000016056.7
      Conserved Domains (1) summary
      COG0596
      Location:45 → 241
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      115957853..115965697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766499.4 → XP_008764721.1  protein ABHD14A isoform X1

      Conserved Domains (2) summary
      COG0596
      Location:45 → 138
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:68 → 177
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0C4.1 GenPept UniProtKB/Swiss-Prot:Q5I0C4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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