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    Zfp483 zinc finger protein 483 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170955, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Zfp483provided by RGD
    Official Full Name
    zinc finger protein 483provided by RGD
    Primary source
    RGD:727958
    See related
    Ensembl:ENSRNOG00000014975 AllianceGenome:RGD:727958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hit10; HIT-10; Znf483; Zkscan16
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF483 (zinc finger protein 483). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 235.9), Adrenal (RPKM 30.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (78558213..78575559)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (73763201..73780511)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (76090015..76103051)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 10 Neighboring gene chaperonin containing Tcp1, subunit 6A (zeta 1), pseudogene 4 Neighboring gene uncharacterized LOC134478984 Neighboring gene prostaglandin reductase 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C25 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 483
    Names
    zinc finger protein HIT-10
    zinc finger with KRAB and SCAN domains 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133422.2 → NP_596913.1  zinc finger protein 483

      See identical proteins and their annotated locations for NP_596913.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6KDV6, F7EN42, Q99PJ8
      Conserved Domains (4) summary
      smart00349
      Location:176 → 229
      KRAB; krueppel associated box
      COG5048
      Location:487 → 730
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 127
      SCAN; SCAN domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      78558213..78575559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109213.2 → XP_038965141.1  zinc finger protein 483 isoform X1

      UniProtKB/TrEMBL
      A6KDV6, F7EN42, Q99PJ8
      Related
      ENSRNOP00000020207.4
      Conserved Domains (4) summary
      smart00349
      Location:176 → 229
      KRAB; krueppel associated box
      COG5048
      Location:487 → 730
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 127
      SCAN; SCAN domain

    2. XM_039109218.2 → XP_038965146.1  zinc finger protein 483 isoform X1

      UniProtKB/TrEMBL
      A6KDV6, F7EN42, Q99PJ8
      Conserved Domains (4) summary
      smart00349
      Location:176 → 229
      KRAB; krueppel associated box
      COG5048
      Location:487 → 730
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 127
      SCAN; SCAN domain

    3. XM_039109219.2 → XP_038965147.1  zinc finger protein 483 isoform X1

      UniProtKB/TrEMBL
      A6KDV6, F7EN42, Q99PJ8
      Conserved Domains (4) summary
      smart00349
      Location:176 → 229
      KRAB; krueppel associated box
      COG5048
      Location:487 → 730
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 127
      SCAN; SCAN domain

    4. XM_039109217.2 → XP_038965145.1  zinc finger protein 483 isoform X1

      UniProtKB/TrEMBL
      A6KDV6, F7EN42, Q99PJ8
      Conserved Domains (4) summary
      smart00349
      Location:176 → 229
      KRAB; krueppel associated box
      COG5048
      Location:487 → 730
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 127
      SCAN; SCAN domain

    5. XM_039109216.2 → XP_038965144.1  zinc finger protein 483 isoform X1

      UniProtKB/TrEMBL
      A6KDV6, F7EN42, Q99PJ8
      Conserved Domains (4) summary
      smart00349
      Location:176 → 229
      KRAB; krueppel associated box
      COG5048
      Location:487 → 730
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 127
      SCAN; SCAN domain

    6. XM_039109214.2 → XP_038965142.1  zinc finger protein 483 isoform X1

      UniProtKB/TrEMBL
      A6KDV6, F7EN42, Q99PJ8
      Conserved Domains (4) summary
      smart00349
      Location:176 → 229
      KRAB; krueppel associated box
      COG5048
      Location:487 → 730
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 127
      SCAN; SCAN domain
    Nucleotide Protein Strain
    Heading Accession and Version

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