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    CG1894 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43378, updated on 11-Apr-2024

    Summary

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    Official Symbol
    CG1894provided by FlyBase
    Primary source
    FLYBASE:FBgn0039585
    Locus tag
    Dmel_CG1894
    See related
    AllianceGenome:FB:FBgn0039585
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1894; dmHAG407; HAT
    Summary
    Predicted to enable histone acetyltransferase activity (H4-K16 specific); histone binding activity; and transcription coregulator activity. Predicted to be involved in negative regulation of transcription, DNA-templated and positive regulation of transcription by RNA polymerase II. Predicted to be part of MSL complex. Orthologous to human KAT8 (lysine acetyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    98D2-98D2; 3-96 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28484557..28486062)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24310279..24311784)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Odorant receptor 98b Neighboring gene long non-coding RNA:CR46106 Neighboring gene beaten path VI Neighboring gene Dynein heavy chain at 89D Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease. Bodai L, et al. Neurodegener Dis, 2012. PMID 21912091, Free PMC Article
    2. The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Yang XJ. Nucleic Acids Res, 2004. PMID 14960713, Free PMC Article
    3. Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex. Jugder BE, et al. Immunity, 2021 Aug 10. PMID 34107298, Free PMC Article
    4. Tracing the origin of the compensasome: evolutionary history of DEAH helicase and MYST acetyltransferase gene families. Sanjuán R, et al. Mol Biol Evol, 2001 Mar. PMID 11230534
    5. Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling. Navarro-Costa P, et al. Nat Commun, 2016 Aug 10. PMID 27507044, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K16 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1894-PA
    NP_651620.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28484557..28486062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143363.3 → NP_651620.1  uncharacterized protein Dmel_CG1894 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651620.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAV6
      Related
      FBpp0084659
      Conserved Domains (2) summary
      pfam01853
      Location:202 → 378
      MOZ_SAS; MOZ/SAS family
      cl17182
      Location:130 → 395
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAV6 Q9VAV6

    Gene LinkOut

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