Acad11 acyl-Coenzyme A dehydrogenase family, member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acad11provided by MGI
Official Full Name: acyl-Coenzyme A dehydrogenase family, member 11provided by MGI
Primary source: MGI:MGI:2143169
See related: Ensembl:ENSMUSG00000090150 AllianceGenome:MGI:2143169
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730439E10Rik
Summary: Predicted to enable medium-chain-acyl-CoA dehydrogenase activity and very-long-chain-acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in central nervous system and retina. Orthologous to human ACAD11 (acyl-CoA dehydrogenase family member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 65.5), kidney adult (RPKM 50.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 56.25 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (103940923..104004855)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (104063724..104127656)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Dcr49 (e-PCR), detects polymorphism
- UniSTS:498972

AI987948 (e-PCR)
- UniSTS:165661

D9Dcr50 (e-PCR), detects polymorphism
- UniSTS:498973

D9Dcr51 (e-PCR), detects polymorphism
- UniSTS:498974

BQ205714 (e-PCR)
- UniSTS:261430

D9Mit148 (e-PCR), detects polymorphism
- UniSTS:131700

Ccrl1 (e-PCR), detects polymorphism
- UniSTS:496040

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables very-long-chain fatty acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-CoA dehydrogenase family member 11

NP_780533.2

EC 1.3.8.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175324.4 → NP_780533.2 acyl-CoA dehydrogenase family member 11

See identical proteins and their annotated locations for NP_780533.2

Status: VALIDATED

Source sequence(s)

AI843434, AK077531

Consensus CDS

CCDS23458.1

UniProtKB/Swiss-Prot

Q80XL6, Q8BK19

UniProtKB/TrEMBL

A0A0R4J0I6

Related

ENSMUSP00000043424.6, ENSMUST00000047799.13

Conserved Domains (3) summary

cd01155
Location:376 → 769

ACAD_FadE2; Acyl-CoA dehydrogenases similar to fadE2

PLN02876
Location:6 → 769

PLN02876; acyl-CoA dehydrogenase

cd05154
Location:42 → 292

ACAD10_11_N-like; N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins