Dmap1 DNA methyltransferase 1-associated protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmap1provided by MGI
Official Full Name: DNA methyltransferase 1-associated protein 1provided by MGI
Primary source: MGI:MGI:1913483
See related: Ensembl:ENSMUSG00000009640 AllianceGenome:MGI:1913483
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DNMAP1; Dmtap1; DNMTAP1; mKIAA1425; 1500016M21Rik
Summary: Enables transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in replication fork. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human DMAP1 (DNA methyltransferase 1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 19.7), CNS E14 (RPKM 18.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.46 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (117531878..117539450, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (117674681..117682321, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic Stem Cells by Crosstalk with PcG Proteins.
Title: MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic Stem Cells by Crosstalk with PcG Proteins.
The results establish Dmap1 as a modulator of cardiac reprogramming and myocytic induction.
Title: CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors.
Consistent with the phenotypes of loss of other members of the TIP60-p400 complex, Dmap1(-/-) mice died during preimplantation in both Dnmt1(+/+) and Dnmt1(V)(/)(V) backgrounds.
Title: Distinct roles of DMAP1 in mouse development.
Dmap1 plays a crucial role in DNA repair, and is indispensable for the maintenance of chromosomal integrity
Title: Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process.
Findings suggest that Bmi1 incorporates Dmap1 in polycomb gene silencing.
Title: Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing.
Data suggest that MAT1-mediated transcriptional repressor (MMTR) is part of the basic cellular machinery for a wide range of transcriptional regulation via interaction with TFIIH and HDAC1.
Title: Corepressor MMTR/DMAP1 is involved in both histone deacetylase 1- and TFIIH-mediated transcriptional repression.
In this study, two-hybrid screening leads to the identification of DNMT1 associated protein, DMAP1, as a Daax-interacting protein.
Title: Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of Swr1 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
part_of nucleosome	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in replication fork	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA methyltransferase 1-associated protein 1

Names: DNMT1 associated protein-1; MAT1-mediated transcriptional repressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419061.1 → NP_001405990.1 DNA methyltransferase 1-associated protein 1

Status: VALIDATED

Source sequence(s)

AL671520

UniProtKB/Swiss-Prot

Q99LM0, Q9CSS9, Q9DB33, Q9JI44
NM_001419062.1 → NP_001405991.1 DNA methyltransferase 1-associated protein 1

Status: VALIDATED

Source sequence(s)

AL671520

UniProtKB/Swiss-Prot

Q99LM0, Q9CSS9, Q9DB33, Q9JI44
NM_001419063.1 → NP_001405992.1 DNA methyltransferase 1-associated protein 1

Status: VALIDATED

Source sequence(s)

AL671520

UniProtKB/Swiss-Prot

Q99LM0, Q9CSS9, Q9DB33, Q9JI44

Related

ENSMUST00000135582.8
NM_023178.3 → NP_075667.1 DNA methyltransferase 1-associated protein 1

See identical proteins and their annotated locations for NP_075667.1

Status: VALIDATED

Source sequence(s)

AL671520

Consensus CDS

CCDS18536.1

UniProtKB/Swiss-Prot

Q99LM0, Q9CSS9, Q9DB33, Q9JI44

Related

ENSMUSP00000099748.4, ENSMUST00000102687.4

Conserved Domains (2) summary

pfam05499
Location:243 → 400

DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)

pfam16282
Location:124 → 203

SANT_DAMP1_like; SANT/Myb-like domain of DAMP1