U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rdh16 retinol dehydrogenase 16 [ Mus musculus (house mouse) ]

    Gene ID: 19683, updated on 11-Apr-2024

    Summary

    Official Symbol
    Rdh16provided by MGI
    Official Full Name
    retinol dehydrogenase 16provided by MGI
    Primary source
    MGI:MGI:1201375
    See related
    Ensembl:ENSMUSG00000069456 AllianceGenome:MGI:1201375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRAD; Rdh6; CRAD1
    Summary
    Enables NAD-retinol dehydrogenase activity and identical protein binding activity. Involved in retinoid metabolic process and steroid metabolic process. Acts upstream of or within 9-cis-retinoic acid biosynthetic process. Located in endoplasmic reticulum lumen and endoplasmic reticulum membrane. Is integral component of organelle membrane. Is expressed in alimentary system; embryo; future spinal cord; liver; and salivary gland. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 24.2), liver adult (RPKM 21.9) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    10 D3; 10 75.7 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127636959..127651715)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127801090..127815846)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 1 (all trans) Neighboring gene STARR-seq mESC enhancer starr_28237 Neighboring gene retinol dehydrogenase 9 Neighboring gene STARR-seq mESC enhancer starr_28238 Neighboring gene STARR-seq mESC enhancer starr_28239 Neighboring gene STARR-seq mESC enhancer starr_28240 Neighboring gene retinol dehydrogenase 18, pseudogene Neighboring gene retinol dehydrogenase 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Clone Names

    • MGC107668

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 11-cis-retinol dehydrogenase IEA
    Inferred from Electronic Annotation
    more info
     
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables all-trans-retinol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of retinoic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinoic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinoid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    retinol dehydrogenase 16
    Names
    cis-retinol/androgen dehydrogenase 1
    retinol dehydrogenase 6
    retinol dehydrogenase type 6
    NP_033066.1
    XP_006513452.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009040.3NP_033066.1  retinol dehydrogenase 16

      See identical proteins and their annotated locations for NP_033066.1

      Status: VALIDATED

      Source sequence(s)
      AC131690, AF030513, AK149404, BY144003
      Consensus CDS
      CCDS24252.1
      UniProtKB/Swiss-Prot
      O54909
      UniProtKB/TrEMBL
      E9Q9P8
      Related
      ENSMUSP00000071573.2, ENSMUST00000071646.2
      Conserved Domains (1) summary
      cd09805
      Location:30306
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127636959..127651715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513389.3XP_006513452.1  retinol dehydrogenase 16 isoform X1

      See identical proteins and their annotated locations for XP_006513452.1

      UniProtKB/Swiss-Prot
      O54909
      UniProtKB/TrEMBL
      E9Q9P8
      Conserved Domains (1) summary
      cd09805
      Location:30306
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs