U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Zmynd10 zinc finger, MYND domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 114602, updated on 30-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Zmynd10provided by MGI
    Official Full Name
    zinc finger, MYND domain containing 10provided by MGI
    Primary source
    MGI:MGI:2387863
    See related
    Ensembl:ENSMUSG00000010044 AllianceGenome:MGI:2387863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Blu
    Summary
    Enables molecular adaptor activity and protein folding chaperone. Involved in outer dynein arm assembly and positive regulation of motile cilium assembly. Acts upstream of or within several processes, including cilium assembly; cilium movement; and protein localization to cilium. Located in apical plasma membrane and cytoplasm. Is expressed in bronchiole epithelium; lung; lung epithelium; nasal cavity epithelium; and nasal cavity respiratory epithelium. Used to study primary ciliary dyskinesia 22. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 22. Orthologous to human ZMYND10 (zinc finger MYND-type containing 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 56.3) and kidney adult (RPKM 6.2) See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    9 F1; 9 58.12 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107424067..107428520)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107546872..107551321)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cytochrome b-561 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E10584 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E3857 Neighboring gene predicted gene, 34106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107453431-107453584 Neighboring gene Ras association (RalGDS/AF-6) domain family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E9335 Neighboring gene predicted gene 9917 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers. Agathanggelou A, et al. Oncogene, 2003 Mar 13. PMID 12629521
    2. Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia. Moore DJ, et al. Am J Hum Genet, 2013 Aug 8. PMID 23891471, Free PMC Article
    3. ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. Cho KJ, et al. PLoS Genet, 2018 Mar. PMID 29601588, Free PMC Article
    4. ZMYND10 functions in a chaperone relay during axonemal dynein assembly. Mali GR, et al. Elife, 2018 Jun 19. PMID 29916806, Free PMC Article
    5. MORC2B is essential for meiotic progression and fertility. Shi B, et al. PLoS Genet, 2018 Jan. PMID 29329290, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (4)  1 citation

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inner dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inner dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inner dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inner dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within outer dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in outer dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger MYND domain-containing protein 10
    Names
    protein BLu

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379079.1 → NP_001366008.1  zinc finger MYND domain-containing protein 10 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 4, encodes isoform 3.
      Source sequence(s)
      AL672219
      Conserved Domains (1) summary
      pfam01753
      Location:351 → 387
      zf-MYND; MYND finger

    2. NM_001379080.1 → NP_001366009.1  zinc finger MYND domain-containing protein 10 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 3, encodes isoform 3.
      Source sequence(s)
      AL672219
      Conserved Domains (1) summary
      pfam01753
      Location:351 → 387
      zf-MYND; MYND finger

    3. NM_001404947.1 → NP_001391876.1  zinc finger MYND domain-containing protein 10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL672219

    4. NM_053253.4 → NP_444483.2  zinc finger MYND domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_444483.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL672219, BC052357, BY284492
      Consensus CDS
      CCDS23493.1
      UniProtKB/Swiss-Prot
      Q3V1P0, Q80W73, Q99ML0
      Related
      ENSMUSP00000010188.8, ENSMUST00000010188.9
      Conserved Domains (1) summary
      pfam01753
      Location:394 → 430
      zf-MYND; MYND finger

    RNA

    1. NR_166465.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672219
      Related
      ENSMUST00000193303.6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107424067..107428520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511630.4 → XP_006511693.1  zinc finger MYND domain-containing protein 10 isoform X1

      Conserved Domains (1) summary
      pfam01753
      Location:432 → 468
      zf-MYND; MYND finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99ML0.2 GenPept UniProtKB/Swiss-Prot:Q99ML0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous