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    Spata6 spermatogenesis associated 6 [ Mus musculus (house mouse) ]

    Gene ID: 67946, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Spata6provided by MGI
    Official Full Name
    spermatogenesis associated 6provided by MGI
    Primary source
    MGI:MGI:1915196
    See related
    Ensembl:ENSMUSG00000034401 AllianceGenome:MGI:1915196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KRP; Hash; Mash; 1700062C23Rik
    Summary
    Enables myosin light chain binding activity. Involved in motile cilium assembly and spermatogenesis. Located in sperm connecting piece. Is expressed in several structures, including adipose tissue; central nervous system; genitourinary system; gut; and liver and biliary system. Orthologous to human SPATA6 (spermatogenesis associated 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 127.0) and bladder adult (RPKM 5.9) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D1; 4 51.53 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (111577151..111686339)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (111719951..111829142)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E2704 Neighboring gene STARR-seq mESC enhancer starr_11088 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1278 Neighboring gene STARR-positive B cell enhancer ABC_E11250 Neighboring gene STARR-seq mESC enhancer starr_11089 Neighboring gene BEN domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_11090 Neighboring gene STARR-seq mESC enhancer starr_11091 Neighboring gene STARR-seq mESC enhancer starr_11092 Neighboring gene STARR-positive B cell enhancer ABC_E4646 Neighboring gene predicted gene, 33192 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:111490159-111490407 Neighboring gene STARR-seq mESC enhancer starr_11094 Neighboring gene STARR-seq mESC enhancer starr_11095 Neighboring gene predicted gene 12961 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 9 Neighboring gene selection and upkeep of intraepithelial T cells 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization, expression pattern and chromosomal localization of the spermatogenesis associated 6 gene (Spata6). Oh C, et al. Mol Hum Reprod, 2003 Jun. PMID 12771232
    2. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Yuan S, et al. Proc Natl Acad Sci U S A, 2015 Feb 3. PMID 25605924, Free PMC Article
    3. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables myosin light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin light chain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm connecting piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm connecting piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 6
    Names
    kinesin-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357231.1 → NP_001344160.1  spermatogenesis-associated protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK005819, AK051574, AK153098, CK622811
      Related
      ENSMUST00000143879.8

    2. NM_026470.3 → NP_080746.3  spermatogenesis-associated protein 6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080746.3

      Status: VALIDATED

      Source sequence(s)
      AK005819, AK051574, AK153098, CK129415
      Consensus CDS
      CCDS38836.1
      UniProtKB/Swiss-Prot
      A2AED7, Q3U6K5, Q3V104, Q8BW97, Q99MU6, Q9D9J1, Q9DAI3
      UniProtKB/TrEMBL
      A2AED8
      Related
      ENSMUSP00000036964.8, ENSMUST00000038868.14
      Conserved Domains (1) summary
      pfam14909
      Location:11 → 149
      SPATA6; Spermatogenesis-assoc protein 6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      111577151..111686339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164380.1 → XP_036020273.1  spermatogenesis-associated protein 6 isoform X2

      Conserved Domains (1) summary
      pfam14909
      Location:1 → 41
      SPATA6; Spermatogenesis-assoc protein 6

    2. XM_006503347.5 → XP_006503410.1  spermatogenesis-associated protein 6 isoform X2

      Conserved Domains (1) summary
      pfam14909
      Location:1 → 41
      SPATA6; Spermatogenesis-assoc protein 6

    3. XM_006503348.5 → XP_006503411.1  spermatogenesis-associated protein 6 isoform X3

      UniProtKB/TrEMBL
      A0PJG4
      Conserved Domains (1) summary
      pfam14909
      Location:3 → 21
      SPATA6; Spermatogenesis-assoc protein 6

    4. XM_030253731.2 → XP_030109591.1  spermatogenesis-associated protein 6 isoform X2

      Conserved Domains (1) summary
      pfam14909
      Location:1 → 41
      SPATA6; Spermatogenesis-assoc protein 6

    5. XM_006503346.5 → XP_006503409.1  spermatogenesis-associated protein 6 isoform X1

      UniProtKB/TrEMBL
      A2AED8
      Conserved Domains (1) summary
      pfam14909
      Location:11 → 79
      SPATA6; Spermatogenesis-assoc protein 6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U6K5.2 GenPept UniProtKB/Swiss-Prot:Q3U6K5

    Gene LinkOut

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