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    L3mbtl3 L3MBTL3 histone methyl-lysine binding protein [ Mus musculus (house mouse) ]

    Gene ID: 237339, updated on 5-Mar-2024

    Summary

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    Official Symbol
    L3mbtl3provided by MGI
    Official Full Name
    L3MBTL3 histone methyl-lysine binding proteinprovided by MGI
    Primary source
    MGI:MGI:2143628
    See related
    Ensembl:ENSMUSG00000039089 AllianceGenome:MGI:2143628
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MBT-1
    Summary
    Predicted to enable chromatin binding activity; histone binding activity; and identical protein binding activity. Acts upstream of or within erythrocyte maturation; granulocyte differentiation; and macrophage differentiation. Located in nucleus. Is expressed in retina. Orthologous to human L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 9.7), CNS E18 (RPKM 6.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See L3mbtl3 in Genome Data Viewer
    Location:
    10 A4; 10 13.67 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (26150361..26252426, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (26274461..26376036, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26120 Neighboring gene STARR-seq mESC enhancer starr_26121 Neighboring gene sterile alpha motif domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_26122 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene Neighboring gene predicted gene, 30034 Neighboring gene STARR-seq mESC enhancer starr_26124 Neighboring gene STARR-seq mESC enhancer starr_26125

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina. Miesfeld JB, et al. Sci Rep, 2018 Jul 5. PMID 29977079, Free PMC Article
    2. Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1. Arai S, et al. EMBO J, 2005 May 18. PMID 15889154, Free PMC Article
    3. The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis. Guo P, et al. Nat Commun, 2022 Nov 5. PMID 36335117, Free PMC Article
    4. RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. Xu T, et al. EMBO J, 2017 Nov 2. PMID 29030483, Free PMC Article
    5. Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase. Leng F, et al. Nat Commun, 2018 Apr 24. PMID 29691401, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The direct binding of L3MBTL3 to the methylated SOX2 protein leads to the recruitment of the CRL4(DCAF5) ubiquitin E3 ligase to target SOX2 protein for ubiquitin-dependent proteolysis.
      Title: Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
    2. L3MBTL3 binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1.
      Title: Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
    3. The mouse MBT-1 protein influences myelopoiesis by transiently enhancing p57(KIP2) expression levels.
      Title: Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90546

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylation-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within erythrocyte maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myeloid cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA methylation-dependent heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lethal(3)malignant brain tumor-like protein 3
    Names
    l(3)mbt-like 3
    l(3)mbt-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347467.3 → NP_001334396.1  lethal(3)malignant brain tumor-like protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091763, AC152953
      Consensus CDS
      CCDS83689.1
      UniProtKB/Swiss-Prot
      Q8BLB7
      Related
      ENSMUSP00000101158.4, ENSMUST00000105519.10
      Conserved Domains (2) summary
      cd09582
      Location:783 → 848
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:426 → 518
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    2. NM_001359254.2 → NP_001346183.1  lethal(3)malignant brain tumor-like protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC091763, AC152953
      Consensus CDS
      CCDS23756.1
      UniProtKB/Swiss-Prot
      Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4
      Related
      ENSMUSP00000037619.7, ENSMUST00000040219.13
      Conserved Domains (3) summary
      cd09582
      Location:808 → 873
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:451 → 543
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:558 → 586
      zf-C2HC; Zinc finger, C2HC type

    3. NM_001359255.2 → NP_001346184.1  lethal(3)malignant brain tumor-like protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC091763, AC152953
      Conserved Domains (2) summary
      cd09582
      Location:732 → 797
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:375 → 467
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    4. NM_001408257.1 → NP_001395186.1  lethal(3)malignant brain tumor-like protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC091763, AC152953
      UniProtKB/Swiss-Prot
      Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4

    5. NM_001408258.1 → NP_001395187.1  lethal(3)malignant brain tumor-like protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091763, AC152953

    6. NM_001408259.1 → NP_001395188.1  lethal(3)malignant brain tumor-like protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC091763, AC152953

    7. NM_172787.4 → NP_766375.1  lethal(3)malignant brain tumor-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_766375.1

      Status: VALIDATED

      Source sequence(s)
      AC091763, AC152953
      Consensus CDS
      CCDS23756.1
      UniProtKB/Swiss-Prot
      Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4
      Related
      ENSMUSP00000133479.2, ENSMUST00000174766.2
      Conserved Domains (3) summary
      cd09582
      Location:808 → 873
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:451 → 543
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:558 → 586
      zf-C2HC; Zinc finger, C2HC type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      26150361..26252426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155774.1 → XP_036011667.1  lethal(3)malignant brain tumor-like protein 3 isoform X4

      Conserved Domains (2) summary
      cd09582
      Location:732 → 797
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:375 → 467
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    2. XM_030245082.2 → XP_030100942.1  lethal(3)malignant brain tumor-like protein 3 isoform X3

      Conserved Domains (2) summary
      cd09582
      Location:757 → 822
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:400 → 492
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    3. XM_036155772.1 → XP_036011665.1  lethal(3)malignant brain tumor-like protein 3 isoform X2

      Conserved Domains (2) summary
      cd09582
      Location:783 → 848
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:426 → 518
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    4. XM_006512733.4 → XP_006512796.1  lethal(3)malignant brain tumor-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006512796.1

      UniProtKB/Swiss-Prot
      Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4
      Conserved Domains (3) summary
      cd09582
      Location:808 → 873
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:451 → 543
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:558 → 586
      zf-C2HC; Zinc finger, C2HC type

    5. XM_030245083.2 → XP_030100943.1  lethal(3)malignant brain tumor-like protein 3 isoform X4

      Conserved Domains (2) summary
      cd09582
      Location:732 → 797
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:375 → 467
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    6. XM_030245081.2 → XP_030100941.1  lethal(3)malignant brain tumor-like protein 3 isoform X2

      Conserved Domains (2) summary
      cd09582
      Location:783 → 848
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:426 → 518
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLB7.1 GenPept UniProtKB/Swiss-Prot:Q8BLB7

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