Pxdn peroxidasin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pxdnprovided by MGI
Official Full Name: peroxidasinprovided by MGI
Primary source: MGI:MGI:1916925
See related: Ensembl:ENSMUSG00000020674 AllianceGenome:MGI:1916925
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: VPO1; mKIAA0230; E330004E07; 2310075M15Rik
Summary: Predicted to enable bromide peroxidase activity and heme binding activity. Predicted to be an extracellular matrix structural constituent. Involved in extracellular matrix organization. Located in collagen-containing extracellular matrix. Is expressed in several structures, including branchial arch; central nervous system; gut; heart; and sensory organ. Human ortholog(s) of this gene implicated in anterior segment dysgenesis 7. Orthologous to human PXDN (peroxidasin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 54.0), limb E14.5 (RPKM 52.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A2; 12 13.0 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (29986641..30067657)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (29936642..30017658)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults.
Title: Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults.
Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in Liver.
Title: Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in Liver.
Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix.
Title: Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix.
these results suggest that PXDN activity is essential in eye development, and also indicate that a single allele of Pxdn gene is sufficient for eye-structure formation and normal visual function.
Title: Biallelic Deletion of Pxdn in Mice Leads to Anophthalmia and Severe Eye Malformation.
Peroxidasin contributes to renal fibrosis in the murine unilateral ureteral obstruction model.
Title: Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model.
we conclude that VPO1 is a crucial regulator of cardiac fibrosis after MI by mediating HOCl/Smad2/3 and ERK1/2 signaling pathways, implying a promising therapeutic target in ischemic cardiomyopathy.
Title: Vascular peroxidase 1 is a novel regulator of cardiac fibrosis after myocardial infarction.
Vpo1 is upregulated in elastase-induced mouse abdominal aortic aneurysmal tissues compared with healthy control tissues.
Title: VPO1 Modulates Vascular Smooth Muscle Cell Phenotypic Switch by Activating Extracellular Signal-regulated Kinase 1/2 (ERK 1/2) in Abdominal Aortic Aneurysms.
Data suggest that VPO1 contributes to oxidation and retention of LDL in vessel walls, and formation foam cells, indicating VPO1 as a novel potential mediator of atherosclerosis.
Title: VPO1 mediates oxidation of LDL and formation of foam cells.
Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit (Col4a1, GPBP, Lamc1, peroxidasin) during uterine reprogramming.
Title: Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming.
Cdkn1b exert its effects via the inhibition of proliferation and is mediated by miR-24 and targeted by the transcription factors FOXO4 and AP4 in the peroxidasin (Pxdn) mutation-induced eye disorders, such as glaucoma.
Title: An examination of the regulatory mechanism of Pxdn mutation-induced eye disorders using microarray analysis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236822

Pxdn (e-PCR), detects polymorphism
- UniSTS:525619

RH127185 (e-PCR)
- UniSTS:208791

RH126859 (e-PCR)
- UniSTS:208792

Pxdn (e-PCR), detects polymorphism
- UniSTS:525566

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	ISO Inferred from Sequence Orthology more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables heme binding	ISO Inferred from Sequence Orthology more info
enables laminin-1 binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on peroxide as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on peroxide as acceptor	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity, acting on peroxide as acceptor	ISO Inferred from Sequence Orthology more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in basement membrane assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in basement membrane assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of basement membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
involved_in extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxidasin homolog

NP_852060.2

EC 1.11.1.7

XP_006515268.1

EC 1.11.1.7

XP_006515269.1

EC 1.11.1.7

XP_036013501.1

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181395.2 → NP_852060.2 peroxidasin homolog precursor

See identical proteins and their annotated locations for NP_852060.2

Status: VALIDATED

Source sequence(s)

AK142872, BC112913, BP772471

Consensus CDS

CCDS25856.1

UniProtKB/Swiss-Prot

A4FU83, E9QNQ9, Q3UQ28

UniProtKB/TrEMBL

B2RX13

Related

ENSMUSP00000113703.2, ENSMUST00000122328.8

Conserved Domains (12) summary

cd05745
Location:443 → 516

Ig3_Peroxidasin; Third immunoglobulin (Ig)-like domain of peroxidasin

cd05746
Location:539 → 607

Ig4_Peroxidasin; Fourth immunoglobulin (Ig)-like domain of peroxidasin

cd09826
Location:861 → 1300

peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins

smart00214
Location:1411 → 1466

VWC; von Willebrand factor (vWF) type C domain

pfam07679
Location:430 → 516

I-set; Immunoglobulin I-set domain

sd00031
Location:109 → 132

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:63 → 84

LRR_RI; leucine-rich repeat [structural motif]

pfam03098
Location:738 → 1279

An_peroxidase; Animal haem peroxidase

pfam12799
Location:107 → 148

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:108 → 167

LRR_8; Leucine rich repeat

cl11960
Location:243 → 330

Ig; Immunoglobulin domain

cl15307
Location:189 → 240

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

29986641..30067657

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515205.4 → XP_006515268.1 peroxidasin homolog isoform X1

UniProtKB/TrEMBL

B2RX13

Conserved Domains (9) summary

cd05745
Location:471 → 544

Ig3_Peroxidasin; Third immunoglobulin (Ig)-like domain of peroxidasin

cd05746
Location:567 → 635

Ig4_Peroxidasin; Fourth immunoglobulin (Ig)-like domain of peroxidasin

cd09826
Location:889 → 1328

peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins

smart00214
Location:1439 → 1494

VWC; von Willebrand factor (vWF) type C domain

sd00031
Location:113 → 127

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:94 → 112

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:160 → 219

LRR_8; Leucine rich repeat

pfam07679
Location:367 → 454

I-set; Immunoglobulin I-set domain

cl15307
Location:217 → 268

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_036157608.1 → XP_036013501.1 peroxidasin homolog isoform X2

Conserved Domains (2) summary

cd09826
Location:170 → 609

peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins

smart00214
Location:720 → 775

VWC; von Willebrand factor (vWF) type C domain
XM_006515206.2 → XP_006515269.1 peroxidasin homolog isoform X2

Conserved Domains (2) summary

cd09826
Location:170 → 609

peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins

smart00214
Location:720 → 775

VWC; von Willebrand factor (vWF) type C domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_177804.2: Suppressed sequence

Description

NM_177804.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.