eis enhanced intracellular survival protein [Mycobacterium tuberculosis H37Rv] - Gene

Summary

Go to the top of the page Help

Gene symbol: eis
Gene description: enhanced intracellular survival protein
Locus tag: Rv2416c
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage: Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

Sequence:: NC_000962.3 (2714124..2715332, complement)

NC_000962.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A major cause of resistance to antitubercular drugs of last resort, aminoglycosides, is overexpression of the Eis (enhanced intracellular survival) enzyme of Mtb, which inactivates aminoglycosides by acetylating them. Effect of Eis mutations on the potency of three Eis inhibitors from different structural families.
Title: Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis.
This study reveals that homologous Eis proteins from pathogenic and nonpathogenic mycobacteria follow different modes of unfolding and demonstrate differential structural stability and activity despite highly similar sequences and oligomeric organization.
Title: Differential thermal stability, conformational stability and unfolding behavior of Eis proteins from Mycobacterium smegmatis and Mycobacterium tuberculosis.
Molecular structure and substrate specificity of the Eis family of arylalkylamine N-acetyltransferases has been reported.
Title: Eis, a novel family of arylalkylamine N-acetyltransferase (EC 2.3.1.87).
eis promoter C14G and C15G mutations do not confer kanamycin resistance in Mycobacterium tuberculosis.
Title: eis Promoter C14G and C15G Mutations Do Not Confer Kanamycin Resistance in Mycobacterium tuberculosis.
Our data demonstrated that one possible mechanism of the MTB evasion of autophagy is that the EIS protein up-regulates IL-10 via Ac-H3 and thus activates Akt/mTOR/p70S6K pathway.
Title: Mycobacterium tuberculosis EIS gene inhibits macrophage autophagy through up-regulation of IL-10 by increasing the acetylation of histone H3.
The results suggest that isolates with eis promoter mutations have consistently lower resistance levels to amikacin, kanamycin, and capreomycin than isolates with the rrs A1401G mutation.
Title: Correlating rrs and eis promoter mutations in clinical isolates of Mycobacterium tuberculosis with phenotypic susceptibility levels to the second-line injectables.
4 proteins( (GrpE, CanB, MoxR1 and Eis) were highly expressed, with two of them (Wag31 and GroES) being uniquely expressed under anaerobic conditions
Title: Suppression of Eis and expression of Wag31 and GroES in Mycobacterium tuberculosis cytosol under anaerobic culture conditions.
eis promoter region is a useful molecular marker of kanamycin resistance in the Moscow region
Title: The role of eis mutations in the development of kanamycin resistance in Mycobacterium tuberculosis isolates from the Moscow region.
Studies indicate that mutations in the rrs, tlyA, eis promoter and gidB genes were associated with amikacin, kanamycin and capreomycin resistance.
Title: Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: a systematic review.
Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7.
Title: Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

General protein information

Go to the top of the page Help

Preferred Names: enhanced intracellular survival protein

NP_216932.2

Eis,GCN5-like N-acetyltransferase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000962.3 Reference assembly

Range

2714124..2715332 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_216932.2 enhanced intracellular survival protein [Mycobacterium tuberculosis H37Rv]

See identical proteins and their annotated locations for NP_216932.2

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A0E8VLD6, A0A0H3LBM3, A0A109SYG5, A0A120IPG9

Conserved Domains (1) summary

COG4552
Location:16 → 401

Eis; Predicted acetyltransferase [General function prediction only]