Zranb1 zinc finger, RAN-binding domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zranb1provided by MGI
Official Full Name: zinc finger, RAN-binding domain containing 1provided by MGI
Primary source: MGI:MGI:106441
See related: Ensembl:ENSMUSG00000030967 AllianceGenome:MGI:106441
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1956; Trabid; D7Wsu87e; 9330160G10Rik
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and thiol-dependent deubiquitinase. Predicted to be involved in several processes, including positive regulation of Wnt signaling pathway; protein deubiquitination; and regulation of cell morphogenesis. Predicted to act upstream of or within Wnt signaling pathway and proteolysis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; and neural retina. Orthologous to human ZRANB1 (zinc finger RANBP2-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 10.0), testis adult (RPKM 9.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 76.32 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (132532905..132588127)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (132931176..132986398)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation.
Title: TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation.
Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis.
Title: Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis.
Trabid regulates inflammatory T cell responses via facilitation of histone modifications at the promoters of Il12 and Il23, which involved deubiqutination and stabilization of the histone demethylase Jmjd2d.
Title: Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Wsu87e (e-PCR), detects polymorphism
- UniSTS:142711

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein K29-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K29-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K33-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K33-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin thioesterase Zranb1

Names: TRAF-binding protein; zinc finger Ran-binding domain-containing protein 1

NP_001349127.1

EC 3.4.19.12

NP_001349128.1

EC 3.4.19.12

NP_997185.1

EC 3.4.19.12

XP_006508032.1

EC 3.4.19.12

XP_011240139.1

EC 3.4.19.12

XP_036009086.1

EC 3.4.19.12

XP_036009087.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362198.2 → NP_001349127.1 ubiquitin thioesterase Zranb1 isoform 2

Status: VALIDATED

Source sequence(s)

AC119806

Consensus CDS

CCDS90343.1

UniProtKB/TrEMBL

A0A1L1SQ24

Related

ENSMUSP00000148867.2, ENSMUST00000215716.2

Conserved Domains (4) summary

smart00547
Location:178 → 201

ZnF_RBZ; Zinc finger domain

sd00029
Location:114 → 133

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam02338
Location:464 → 612

OTU; OTU-like cysteine protease

pfam18418
Location:272 → 367

AnkUBD; Ankyrin ubiquitin-binding domain
NM_001362199.2 → NP_001349128.1 ubiquitin thioesterase Zranb1 isoform 2

Status: VALIDATED

Source sequence(s)

AC119806

Consensus CDS

CCDS90343.1

UniProtKB/TrEMBL

A0A1L1SQ24

Conserved Domains (4) summary

smart00547
Location:178 → 201

ZnF_RBZ; Zinc finger domain

sd00029
Location:114 → 133

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam02338
Location:464 → 612

OTU; OTU-like cysteine protease

pfam18418
Location:272 → 367

AnkUBD; Ankyrin ubiquitin-binding domain
NM_207302.3 → NP_997185.1 ubiquitin thioesterase Zranb1 isoform 1

See identical proteins and their annotated locations for NP_997185.1

Status: VALIDATED

Source sequence(s)

AC119806

Consensus CDS

CCDS21929.1

UniProtKB/Swiss-Prot

Q7M760

Related

ENSMUSP00000101763.2, ENSMUST00000106157.8

Conserved Domains (4) summary

smart00547
Location:152 → 175

ZnF_RBZ; Zinc finger domain

sd00029
Location:88 → 107

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam02338
Location:438 → 586

OTU; OTU-like cysteine protease

pfam18418
Location:246 → 341

AnkUBD; Ankyrin ubiquitin-binding domain

RNA

NR_155454.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC119806
NR_163812.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC119806

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

132532905..132588127

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241837.4 → XP_011240139.1 ubiquitin thioesterase Zranb1 isoform X2

See identical proteins and their annotated locations for XP_011240139.1

Conserved Domains (1) summary

pfam02338
Location:112 → 260

OTU; OTU-like cysteine protease
XM_036153194.1 → XP_036009087.1 ubiquitin thioesterase Zranb1 isoform X2

Conserved Domains (1) summary

pfam02338
Location:112 → 260

OTU; OTU-like cysteine protease
XM_036153193.1 → XP_036009086.1 ubiquitin thioesterase Zranb1 isoform X1

UniProtKB/TrEMBL

A0A1B0GQZ6

Related

ENSMUSP00000147317.2, ENSMUST00000210507.2

Conserved Domains (3) summary

smart00547
Location:178 → 201

ZnF_RBZ; Zinc finger domain

sd00029
Location:114 → 133

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam18418
Location:272 → 361

AnkUBD; Ankyrin ubiquitin-binding domain
XM_006507969.4 → XP_006508032.1 ubiquitin thioesterase Zranb1 isoform X2

See identical proteins and their annotated locations for XP_006508032.1

Conserved Domains (1) summary

pfam02338
Location:112 → 260

OTU; OTU-like cysteine protease