Oasl 2'-5'-oligoadenylate synthetase-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oaslprovided by RGD
Official Full Name: 2'-5'-oligoadenylate synthetase-likeprovided by RGD
Primary source: RGD:1308586
See related: Ensembl:ENSRNOG00000001187 AllianceGenome:RGD:1308586
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oasl1
Summary: Predicted to enable DNA binding activity and double-stranded RNA binding activity. Predicted to be involved in several processes, including negative regulation of viral genome replication; positive regulation of RIG-I signaling pathway; and regulation of ribonuclease activity. Predicted to act upstream of or within interleukin-27-mediated signaling pathway. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in cytosol; membrane; and nucleoplasm. Orthologous to human OASL (2'-5'-oligoadenylate synthetase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 77.9), Spleen (RPKM 54.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12q16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (47343551..47356509, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (41682900..41695641, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (47444138..47456680, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables 2'-5'-oligoadenylate synthetase activity	ISO Inferred from Sequence Orthology more info
NOT enables 2'-5'-oligoadenylate synthetase activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-27-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2'-5'-oligoadenylate synthase-like protein 1

Names: 2'-5' oligoadenylate synthetase-like 1; 59 kDa 2'-5'-oligoadenylate synthase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009681.1 → NP_001009681.1 2'-5'-oligoadenylate synthase-like protein 1

See identical proteins and their annotated locations for NP_001009681.1

Status: PROVISIONAL

Source sequence(s)

AY227756

UniProtKB/Swiss-Prot

G3V645, Q5MYW3

Related

ENSRNOP00000001570.3, ENSRNOT00000001570.5

Conserved Domains (5) summary

cd05400
Location:29 → 209

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

smart00213
Location:431 → 499

UBQ; Ubiquitin homologues

pfam00240
Location:436 → 502

ubiquitin; Ubiquitin family

pfam10421
Location:167 → 347

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

cl00155
Location:351 → 430

UBQ; Ubiquitin-like proteins