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    Rad9b RAD9 checkpoint clamp component B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363924, updated on 2-May-2024

    Summary

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    Official Symbol
    Rad9bprovided by RGD
    Official Full Name
    RAD9 checkpoint clamp component Bprovided by RGD
    Primary source
    RGD:1308223
    See related
    Ensembl:ENSRNOG00000021480 AllianceGenome:RGD:1308223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in DNA integrity checkpoint signaling; DNA repair; and cellular response to ionizing radiation. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Orthologous to human RAD9B (RAD9 checkpoint clamp component B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 80.5), Muscle (RPKM 52.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12q16
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (39878221..39909254)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34217868..34248380)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39699076..39731218)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene GPN-loop GTPase 3 Neighboring gene family with sequence similarity 216, member A Neighboring gene uncharacterized LOC134481297 Neighboring gene VPS29 retromer complex component Neighboring gene uncharacterized LOC108352448 Neighboring gene protein phosphatase targeting COQ7 Neighboring gene tectonic family member 1 Neighboring gene hydrogen voltage-gated channel 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. Hopkins KM, et al. Cancer Res, 2003 Sep 1. PMID 14500360
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of RAD9B in the mesostriatal system of rats and humans: Overexpression in a 6-OHDA rat model of Parkinson's disease.
      Title: Expression of RAD9B in the mesostriatal system of rats and humans: Overexpression in a 6-OHDA rat model of Parkinson's disease.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124758

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to ionizing radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of checkpoint clamp complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of checkpoint clamp complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell cycle checkpoint control protein RAD9B
    Names
    DNA repair exonuclease rad9 homolog B
    cell cycle checkpoint control protein RAD9B homolog
    NP_001025213.2
    XP_008767463.1
    XP_008767466.1
    XP_017453901.1
    XP_017453902.1
    XP_038945561.1
    XP_038945562.1
    XP_038945563.1
    XP_038945565.1
    XP_063127631.1
    XP_063127632.1
    XP_063127633.1
    XP_063127634.1
    XP_063127635.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030042.2 → NP_001025213.2  cell cycle checkpoint control protein RAD9B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q499V3
      UniProtKB/TrEMBL
      A0A8L2QM66, A6J1A5
      Related
      ENSRNOP00000042520.4, ENSRNOT00000048454.4
      Conserved Domains (1) summary
      pfam04139
      Location:21 → 278
      Rad9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      39878221..39909254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271562.1 → XP_063127632.1  cell cycle checkpoint control protein RAD9B isoform X3

    2. XM_063271561.1 → XP_063127631.1  cell cycle checkpoint control protein RAD9B isoform X1

      UniProtKB/TrEMBL
      A6J1A6

    3. XM_039089633.2 → XP_038945561.1  cell cycle checkpoint control protein RAD9B isoform X1

      UniProtKB/TrEMBL
      A6J1A6
      Conserved Domains (1) summary
      pfam04139
      Location:1 → 165
      Rad9

    4. XM_017598412.3 → XP_017453901.1  cell cycle checkpoint control protein RAD9B isoform X1

      UniProtKB/TrEMBL
      A6J1A6
      Conserved Domains (1) summary
      pfam04139
      Location:1 → 165
      Rad9

    5. XM_063271563.1 → XP_063127633.1  cell cycle checkpoint control protein RAD9B isoform X1

      UniProtKB/TrEMBL
      A6J1A6

    6. XM_063271565.1 → XP_063127635.1  cell cycle checkpoint control protein RAD9B isoform X7

    7. XM_008769241.3 → XP_008767463.1  cell cycle checkpoint control protein RAD9B isoform X2

      UniProtKB/Swiss-Prot
      Q499V3
      Conserved Domains (2) summary
      cd00577
      Location:17 → 257
      PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
      pfam04139
      Location:21 → 258
      Rad9; Rad9

    8. XM_039089637.2 → XP_038945565.1  cell cycle checkpoint control protein RAD9B isoform X5

      Conserved Domains (1) summary
      pfam04139
      Location:21 → 257
      Rad9

    9. XM_039089634.2 → XP_038945562.1  cell cycle checkpoint control protein RAD9B isoform X4

      Conserved Domains (1) summary
      pfam04139
      Location:21 → 203
      Rad9

    10. XM_063271564.1 → XP_063127634.1  cell cycle checkpoint control protein RAD9B isoform X6

    11. XM_017598413.3 → XP_017453902.1  cell cycle checkpoint control protein RAD9B isoform X1

      UniProtKB/TrEMBL
      A6J1A6
      Conserved Domains (1) summary
      pfam04139
      Location:1 → 165
      Rad9

    12. XM_039089635.2 → XP_038945563.1  cell cycle checkpoint control protein RAD9B isoform X1

      UniProtKB/TrEMBL
      A6J1A6
      Conserved Domains (1) summary
      pfam04139
      Location:1 → 165
      Rad9

    13. XM_008769244.4 → XP_008767466.1  cell cycle checkpoint control protein RAD9B isoform X1

      See identical proteins and their annotated locations for XP_008767466.1

      UniProtKB/TrEMBL
      A6J1A6
      Conserved Domains (1) summary
      pfam04139
      Location:1 → 165
      Rad9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499V3.1 GenPept UniProtKB/Swiss-Prot:Q499V3

    Gene LinkOut

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