Abcc2 ATP binding cassette subfamily C member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcc2provided by RGD
Official Full Name: ATP binding cassette subfamily C member 2provided by RGD
Primary source: RGD:2366
See related: Ensembl:ENSRNOG00000046727 AllianceGenome:RGD:2366
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mrp; Mrp2; cMRP; Cmoat
Summary: Enables ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Involved in several processes, including carboxylic acid transport; cellular response to cytokine stimulus; and cellular response to lipid. Located in brush border membrane and intracellular canaliculus. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal disease; and visual epilepsy. Biomarker of several diseases, including bilirubin metabolic disorder; fatty liver disease; primary biliary cholangitis; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); drug-induced hepatitis; leukemia (multiple); and non-alcoholic fatty liver disease. Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1630.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (252613875..252672459)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (242664657..242723239)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (263554426..263612556)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multidrug resistance-associated protein 2 is negatively regulated by oxidative stress in rat intestine via a posttranslational mechanism. Impact on its membrane barrier function.
Title: Multidrug resistance-associated protein 2 is negatively regulated by oxidative stress in rat intestine via a posttranslational mechanism. Impact on its membrane barrier function.
Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon-like peptide-2-mediated mechanism.
Title: Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon-like peptide-2-mediated mechanism.
we demonstrate redistribution of intestinal MRP2 between plasma membrane and intracellular membrane in rat jejunum and in Caco-2 cells in response to db-cAMP and estradiol-17beta-D-glucuronide
Title: Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17β-D-glucuronide in rat intestine and Caco-2 cells.
In conclusion, our data supports the hypothesis that isoniazid can induce liver injury via the down-regulation of hepatic efflux transporters BSEP and MRP2, and the SIRT1/FXR pathway may be the primary regulator with regard to the expression of transporters and the biosynthesis of bile acids in the liver.
Title: Dysregulation of BSEP and MRP2 May Play an Important Role in Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats and HepG2 Cells.
Bile transporters OATP1/MRP2 mRNA expression ratio in liver tissue decreased with dimethylnitrosamine-induced liver injury, model of liver cirrhosis.
Title: Pre-Hepatectomy Assessment of Bile Transporter Expression by Gadoxetic Acid-Enhanced MRI in a Rat Model of Liver Cirrhosis.
GLP-2 can prevent down-regulation of intestinal expression and activity of Mrp2 and P-gp in endotoxemic rats.
Title: Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats.
Calculus Bovis administration can alleviate liver injury and up-regulate the expression of BSEP and MRP2 in 17alpha-ethynylestradiol-induced cholestasis by a mechanism that may involve inhibiting the activated PI3K/Akt signaling pathway.
Title: Up-regulation of BSEP and MRP2 by Calculus Bovis administration in 17α-ethynylestradiol-induced cholestasis: Involvement of PI3K/Akt signaling pathway.
The data of this study show increased Abcc1, Abcc2, and Abcc4 mRNA expression at the BBB in response to H/R stress and that Abcc gene expression is regulated by Nrf2 signaling.
Title: Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress.
results suggest that YZH has protective effect against ANIT-induced intrahepatic cholestasis in rats, through upregulation of Mrp2 and Bsep expressions
Title: Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions.
Abcc2 role in cholestasis: EGFR is a key factor in the alteration of Abcc2 canalicular transporter function in hepatocytes.
Title: EGFR participates downstream of ERα in estradiol-17β-D-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type glutathione S-conjugate transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type glutathione S-conjugate transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ABC-type glutathione S-conjugate transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables bilirubin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables bilirubin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables bilirubin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibiotic metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in benzylpenicillin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bile acid and bile salt transport	IEA Inferred from Electronic Annotation more info
involved_in bile acid and bile salt transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
involved_in bile acid and bile salt transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in bile acid signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in bilirubin transport	IEA Inferred from Electronic Annotation more info
involved_in bilirubin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bilirubin transport	ISO Inferred from Sequence Orthology more info
involved_in canalicular bile acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-6	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in detoxification of mercury ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular chloride ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in leukotriene transport	IEA Inferred from Electronic Annotation more info
involved_in leukotriene transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukotriene transport	ISO Inferred from Sequence Orthology more info
involved_in mercury ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organic anion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organic anion transport	TAS Traceable Author Statement more info	PubMed
involved_in prostaglandin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bile acid secretion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to antineoplastic agent	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to arsenic-containing substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucagon	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in thyroid hormone transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transepithelial transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transepithelial transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic export from cell	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic export from cell	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport across blood-brain barrier	IGI Inferred from Genetic Interaction more info	PubMed
involved_in xenobiotic transport across blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in intercellular canaliculus	IEA Inferred from Electronic Annotation more info
located_in intercellular canaliculus	ISO Inferred from Sequence Orthology more info
located_in intracellular canaliculus	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family C member 2

Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2; cMrp2/cMoat canalicular apical conjugate export pump; calicular multispecific organic anion transporter; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter 1; multidrug resistance-associated protein 2

NP_036965.1

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012833.2 → NP_036965.1 ATP-binding cassette sub-family C member 2

See identical proteins and their annotated locations for NP_036965.1

Status: REVIEWED

Source sequence(s)

JAXUCZ010000001, L49379, X96393

UniProtKB/Swiss-Prot

Q63120, Q63145

UniProtKB/TrEMBL

A0A8I6G7X8

Related

ENSRNOP00000064799.1, ENSRNOT00000070861.3

Conserved Domains (4) summary

TIGR00957
Location:7 → 1533

MRP_assoc_pro; multi drug resistance-associated protein (MRP)

cd03244
Location:1294 → 1514

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:633 → 834

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

pfam00664
Location:979 → 1245

ABC_membrane; ABC transporter transmembrane region