SULT4A1 sulfotransferase family 4A member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SULT4A1provided by HGNC
Official Full Name: sulfotransferase family 4A member 1provided by HGNC
Primary source: HGNC:HGNC:14903
See related: Ensembl:ENSG00000130540 MIM:608359; AllianceGenome:HGNC:14903
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NST; BRSTL1; SULTX3; BR-STL-1; DJ388M5.3; hBR-STL-1
Summary: This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 30.9), duodenum (RPKM 4.1) and 2 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 22q13.31

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (43824509..43862513, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (44307367..44345097, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (44220389..44258393, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
Title: Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
Study in SULT4A1 knockout mice demonstrates that depletion of SULT4A1 induces oxidative stress in neurons and expression of SULT4A1 in human SH-SY5Y cells protects against oxidative-stress-induced mitochondrial dysfunction and cell death. Results suggest that SULT4A1 may have a crucial protective function against mitochondrial dysfunction and oxidative stress.
Title: SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells.
Study using SH-SY5Y cells, human induced pluripotent stem cells, and mouse embryonic tissue revealed time-dependent changes in SULT4A1 protein and MBNL/CELF protein during differentiation supported their role in correctly splicing the SULT4A1 mRNA. Furthermore, ectopic expression of each factor produced efficient splicing in the minigene assay as well as correct splicing of the endogenous SULT4A1 mRNA.
Title: The MBNL/CELF Splicing Factors Regulate Cytosolic Sulfotransferase 4A1 Protein Expression during Cell Differentiation.
These results show that SULT4A1 is widely expressed in human tissues, but mostly as a splice variant that produces a rapidly degraded protein. Dimerization protects the protein from degradation.
Title: Expression of the orphan cytosolic sulfotransferase SULT4A1 and its major splice variant in human tissues and cells: dimerization, degradation and polyubiquitination.
Across three psychiatric disorders (n=2815 patients), we observed no consistent association between SULT4A1-1 status and atypical antipsychotic effect
Title: SULT4A1 haplotype: conflicting results on its role as a biomarker of antipsychotic response.
This study provides a second replication of superior olanzapine response in SULT4A1-1-positive subjects compared with SULT4A1-1-negative subjects.
Title: Replication of SULT4A1-1 as a pharmacogenetic marker of olanzapine response and evidence of lower weight gain in the high response group.
determination of SULT4A1-1 haplotype status might be useful for identifying patients who show an enhanced response to long-term olanzapine treatment.
Title: Evidence for a SULT4A1 haplotype correlating with baseline psychopathology and atypical antipsychotic response.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Cytosolic SULT4A1 interacts with PIN1.
Title: Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1.
These results provide the first evidence of how genetic variation in Sult4A1 may be related to clinical symptoms and cognitive function in schizophrenia
Title: Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

G19733 (e-PCR)
- UniSTS:26883

A001X01 (e-PCR)
- UniSTS:26884

A003P41 (e-PCR)
- UniSTS:75066

G65394 (e-PCR)
- UniSTS:166523

D22S1165 (e-PCR), detects polymorphism
- UniSTS:24188

G65436 (e-PCR)
- UniSTS:166524

G65437 (e-PCR)
- UniSTS:166525

G65391 (e-PCR)
- UniSTS:166530

G65392 (e-PCR)
- UniSTS:166531

G65393 (e-PCR)
- UniSTS:166532

IB1320 (e-PCR)
- UniSTS:11427

D22S1012E (e-PCR)
- UniSTS:84152

D22S297 (e-PCR)
- UniSTS:147642

SULT4A1_2458 (e-PCR)
- UniSTS:281036

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfotransferase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in dendrite arborization	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: sulfotransferase 4A1

Names: ST4A1; brain sulfotransferase-like protein; hBR-STL; nervous system cytosolic sulfotransferase; nervous system sulfotransferase; sulfotransferase-related protein

NP_055166.1

EC 2.8.2.-

XP_011528422.1

EC 2.8.2.-

XP_011528423.1

EC 2.8.2.-

XP_047297277.1

EC 2.8.2.-

XP_047297278.1

EC 2.8.2.-

XP_054181480.1

EC 2.8.2.-

XP_054181481.1

EC 2.8.2.-

XP_054181482.1

EC 2.8.2.-

XP_054181483.1

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014351.4 → NP_055166.1 sulfotransferase 4A1

See identical proteins and their annotated locations for NP_055166.1

Status: REVIEWED

Source sequence(s)

AF251263, Z97055

Consensus CDS

CCDS14051.1

UniProtKB/Swiss-Prot

B2R7N3, O43728, Q9BR01

UniProtKB/TrEMBL

B7Z320

Related

ENSP00000332565.4, ENST00000330884.9

Conserved Domains (1) summary

pfam00685
Location:45 → 277

Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000022.11 Reference GRCh38.p14 Primary Assembly

Range

43824509..43862513 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011530121.2 → XP_011528423.1 sulfotransferase 4A1 isoform X2

See identical proteins and their annotated locations for XP_011528423.1

UniProtKB/TrEMBL

B7Z2E1

Conserved Domains (1) summary

cl21551
Location:59 → 164

Sulfotransfer_1; Sulfotransferase domain
XM_047441322.1 → XP_047297278.1 sulfotransferase 4A1 isoform X4
XM_047441321.1 → XP_047297277.1 sulfotransferase 4A1 isoform X1

Related

ENSP00000388285.1, ENST00000422525.1
XM_011530120.4 → XP_011528422.1 sulfotransferase 4A1 isoform X3

Conserved Domains (1) summary

pfam00685
Location:45 → 167

Sulfotransfer_1; Sulfotransferase domain

RNA

XR_937839.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060946.1 Alternate T2T-CHM13v2.0

Range

44307367..44345097 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054325506.1 → XP_054181481.1 sulfotransferase 4A1 isoform X2

UniProtKB/TrEMBL

B7Z2E1
XM_054325508.1 → XP_054181483.1 sulfotransferase 4A1 isoform X4
XM_054325505.1 → XP_054181480.1 sulfotransferase 4A1 isoform X1
XM_054325507.1 → XP_054181482.1 sulfotransferase 4A1 isoform X3

RNA

XR_008485384.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_176874.1: Suppressed sequence

Description

NM_176874.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.