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    Cald1 caldesmon 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25687, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Cald1provided by RGD
    Official Full Name
    caldesmon 1provided by RGD
    Primary source
    RGD:2256
    See related
    Ensembl:ENSRNOG00000010233 AllianceGenome:RGD:2256
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    l-Cad
    Summary
    Enables actin binding activity. Involved in actin filament bundle assembly and positive regulation of protein binding activity. Located in several cellular components, including actin filament; dendritic spine; and postsynaptic density. Orthologous to human CALD1 (caldesmon 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 462.7), Uterus (RPKM 322.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cald1 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (64232906..64414085)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63265781..63446938)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (62103948..62291375)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member B7 Neighboring gene bisphosphoglycerate mutase Neighboring gene uncharacterized LOC120102254 Neighboring gene AGBL carboxypeptidase 3 Neighboring gene transmembrane protein 140 Neighboring gene cell cycle regulator of NHEJ

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glucocorticoid suppresses dendritic spine development mediated by down-regulation of caldesmon expression. Tanokashira D, et al. J Neurosci, 2012 Oct 17. PMID 23077044, Free PMC Article
    2. Caldesmon regulates axon extension through interaction with myosin II. Morita T, et al. J Biol Chem, 2012 Jan 27. PMID 22158623, Free PMC Article
    3. l-Caldesmon regulates proliferation and migration of vascular smooth muscle cells and inhibits neointimal formation after angioplasty. Yokouchi K, et al. Arterioscler Thromb Vasc Biol, 2006 Oct. PMID 16888241
    4. Caldesmon is an integral component of podosomes in smooth muscle cells. Eves R, et al. J Cell Sci, 2006 May 1. PMID 16595550
    5. Bladder smooth muscle cell phenotypic changes and implication of expression of contractile proteins (especially caldesmon) in rats after partial outlet obstruction. Matsumoto S, et al. Int J Urol, 2003 Jun. PMID 12757606

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. distribution of the actin-binding protein caldesmon in spleen and lymph nodes of mice and rats
      Title: The actin-binding protein caldesmon is in spleen and lymph nodes predominately expressed by smooth-muscle cells, reticular cells, and follicular dendritic cells.
    2. CaD stabilizes the F-actin dynamics in spines, thereby enlarging the spine heads, whereas CaD knockdown decreases the spine-head size via destabilization of the F-actin dynamics.
      Title: Glucocorticoid suppresses dendritic spine development mediated by down-regulation of caldesmon expression.
    3. caldesmon is an important regulator of axon development.
      Title: Caldesmon regulates axon extension through interaction with myosin II.
    4. Overexpression of l-CaD suppressed cell growth and survival in VSMCs and inhibited neointimal formation after angioplasty, partly by regulating cytoskeletal tension-FAK-ERK axis. )
      Title: l-Caldesmon regulates proliferation and migration of vascular smooth muscle cells and inhibits neointimal formation after angioplasty.
    5. Caldesmon binds and stabilizes actin filaments, as well as regulates actin-myosin interaction in a calcium (Ca2+)/calmodulin (CaM)- and/or phosphorylation-dependent manner. (Review)
      Title: Diversification of caldesmon-linked actin cytoskeleton in cell motility.
    6. Stretch activates myometrium via ERK, caldesmon and focal adhesion signaling
      Title: Stretch activates human myometrium via ERK, caldesmon and focal adhesion signaling.
    7. This study reports a novel molecular mechanism (caldesmon), as well as a structural basis (podosomes/rosettes), to show how p53 can act as an anti-motility/invasion/metastasis agent.
      Title: p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon.
    8. The smaller C-terminal region contains the minimum regulatory domain responsible for the inhibition of actomyosin ATPase, and for the binding to actin, calmodulin and TM.
      Title: Role of the basic C-terminal half of caldesmon in its regulation of F-actin: comparison between caldesmon and calponin.
    9. Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation.
      Title: Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation.
    10. caldesmon was most markedly expressed in bladder smooth muscle after partial outlet obstruction
      Title: Bladder smooth muscle cell phenotypic changes and implication of expression of contractile proteins (especially caldesmon) in rats after partial outlet obstruction.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in female pregnancy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in response to transforming growth factor beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cap IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cap ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    non-muscle caldesmon
    Names
    CDM
    L-caldesmon
    h-caldesmon

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398578.1 → NP_001385507.1  non-muscle caldesmon isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IEM4
      Related
      ENSRNOP00000068857.2, ENSRNOT00000086377.2
      Conserved Domains (1) summary
      pfam02029
      Location:53 → 524
      Caldesmon

    2. NM_013146.4 → NP_037278.2  non-muscle caldesmon isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q62736
      UniProtKB/TrEMBL
      A6IEM5
      Related
      ENSRNOP00000043767.3, ENSRNOT00000041264.4
      Conserved Domains (1) summary
      pfam02029
      Location:47 → 518
      Caldesmon

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      64232906..64414085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285627.1 → XP_063141697.1  non-muscle caldesmon isoform X5

    2. XM_063285628.1 → XP_063141698.1  non-muscle caldesmon isoform X6

      UniProtKB/TrEMBL
      A0A8I6GCL3

    3. XM_063285630.1 → XP_063141700.1  non-muscle caldesmon isoform X9

    4. XM_006236261.5 → XP_006236323.1  non-muscle caldesmon isoform X11

      See identical proteins and their annotated locations for XP_006236323.1

      UniProtKB/TrEMBL
      A0A8I6A6T4
      Conserved Domains (1) summary
      pfam02029
      Location:53 → 524
      Caldesmon

    5. XM_063285623.1 → XP_063141693.1  non-muscle caldesmon isoform X4

    6. XM_063285631.1 → XP_063141701.1  non-muscle caldesmon isoform X12

      UniProtKB/TrEMBL
      A6IEM4

    7. XM_063285624.1 → XP_063141694.1  non-muscle caldesmon isoform X4

    8. XM_017592487.3 → XP_017447976.2  non-muscle caldesmon isoform X10

    9. XM_063285625.1 → XP_063141695.1  non-muscle caldesmon isoform X4

    10. XM_063285632.1 → XP_063141702.1  non-muscle caldesmon isoform X12

      UniProtKB/TrEMBL
      A6IEM4

    11. XM_063285633.1 → XP_063141703.1  non-muscle caldesmon isoform X12

      UniProtKB/TrEMBL
      A6IEM4

    12. XM_063285626.1 → XP_063141696.1  non-muscle caldesmon isoform X4

    13. XM_006236262.5 → XP_006236324.2  non-muscle caldesmon isoform X10

    14. XM_063285621.1 → XP_063141691.1  non-muscle caldesmon isoform X2

    15. XM_063285622.1 → XP_063141692.1  non-muscle caldesmon isoform X3

    16. XM_006236260.5 → XP_006236322.3  non-muscle caldesmon isoform X8

    17. XM_063285620.1 → XP_063141690.1  non-muscle caldesmon isoform X1

    18. XM_063285629.1 → XP_063141699.1  non-muscle caldesmon isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62736.1 GenPept UniProtKB/Swiss-Prot:Q62736

    Gene LinkOut

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