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    Igfbp4 insulin-like growth factor binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 16010, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Igfbp4provided by MGI
    Official Full Name
    insulin-like growth factor binding protein 4provided by MGI
    Primary source
    MGI:MGI:96439
    See related
    Ensembl:ENSMUSG00000017493 AllianceGenome:MGI:96439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Deb2; IBP-4; IGFBP-4
    Summary
    Enables insulin-like growth factor binding activity. Acts upstream of or within several processes, including positive regulation of signal transduction; regulation of glucose metabolic process; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; early embryo; female reproductive system; limb; and lung. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 884.2), subcutaneous fat pad adult (RPKM 473.1) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 62.92 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98930820..98943481)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99040005..99052655)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30695 Neighboring gene gap junction protein, delta 3 Neighboring gene topoisomerase (DNA) II alpha Neighboring gene STARR-positive B cell enhancer ABC_E17 Neighboring gene predicted gene, 23451 Neighboring gene tensin 4 Neighboring gene STARR-positive B cell enhancer ABC_E377 Neighboring gene STARR-seq mESC enhancer starr_30701 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:99009129-99009367 Neighboring gene C-C motif chemokine receptor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IGFBP-4 enhances VEGF-induced angiogenesis in a mouse model of myocardial infarction. Wo D, et al. J Cell Mol Med, 2020 Aug. PMID 32597006, Free PMC Article
    2. IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots. Maridas DE, et al. Endocrinology, 2017 Oct 1. PMID 28938423, Free PMC Article
    3. IGFBP-4 regulates adult skeletal growth in a sex-specific manner. Maridas DE, et al. J Endocrinol, 2017 Apr. PMID 28184001, Free PMC Article
    4. Immunohistochemical study on the distribution of insulin-like growth factor-binding protein 4 in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis. Kang DW, et al. Ann Anat, 2008 Dec 20. PMID 18823765
    5. Synthesis of the blood circulating C-terminal fragment of insulin-like growth factor (IGF)-binding protein-4 in its native conformation. Crystallization, heparin and IGF binding, and osteogenic activity. Fernández-Tornero C, et al. J Biol Chem, 2005 May 13. PMID 15735305

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma.
      Title: Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma.
    2. The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
      Title: The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
    3. Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy.
      Title: Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy.
    4. IGFBP-4 enhances VEGF-induced angiogenesis in a mouse model of myocardial infarction.
      Title: IGFBP-4 enhances VEGF-induced angiogenesis in a mouse model of myocardial infarction.
    5. Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence.
      Title: Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence.
    6. Igfbp4 is required for inguinal fat expansion in female mice but not in male mice. However, gonadal WAT expansion, which is prevented by estrogen during high-fat diet, does not require Igfbp4.
      Title: IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots.
    7. IGFBP-4 modulates the skeleton in a gender-specific manner, acting as both a cell autonomous and cell non-autonomous factor.
      Title: IGFBP-4 regulates adult skeletal growth in a sex-specific manner.
    8. exerts a negative effect on basal intestinal growth but plays a positive regulatory role in the intestinotropic actions of GLP-2
      Title: IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine.
    9. IGF-1/IGFbp4 signaling regulated the post-developmental adipose tissue expansion.
      Title: Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.
    10. Igfbp2-5 are expressed in distinct and complementary patterns during cochlear development.
      Title: Expression of insulin-like growth factor binding proteins during mouse cochlear development.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin-like growth factor I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of glucose metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within type B pancreatic cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein 4
    Names
    Band 3A
    IGF-binding protein 4
    differentially expressed in B16F10 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010517.4 → NP_034647.1  insulin-like growth factor-binding protein 4 precursor

      See identical proteins and their annotated locations for NP_034647.1

      Status: VALIDATED

      Source sequence(s)
      AI838737, AL591067
      Consensus CDS
      CCDS25371.1
      UniProtKB/Swiss-Prot
      O35666, P47879, Q3TMV0
      UniProtKB/TrEMBL
      Q8BSM9
      Related
      ENSMUSP00000017637.7, ENSMUST00000017637.13
      Conserved Domains (2) summary
      smart00121
      Location:25 → 101
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:170 → 245
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98930820..98943481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245599.2 → XP_030101459.1  insulin-like growth factor-binding protein 4 isoform X1

      UniProtKB/Swiss-Prot
      O35666, P47879, Q3TMV0
      UniProtKB/TrEMBL
      Q8BSM9
      Conserved Domains (2) summary
      smart00121
      Location:25 → 101
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:170 → 245
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    2. XM_036156346.1 → XP_036012239.1  insulin-like growth factor-binding protein 4 isoform X1

      UniProtKB/Swiss-Prot
      O35666, P47879, Q3TMV0
      UniProtKB/TrEMBL
      Q8BSM9
      Conserved Domains (2) summary
      smart00121
      Location:25 → 101
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:170 → 245
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    3. XM_030245598.1 → XP_030101458.1  insulin-like growth factor-binding protein 4 isoform X1

      UniProtKB/Swiss-Prot
      O35666, P47879, Q3TMV0
      UniProtKB/TrEMBL
      Q8BSM9
      Conserved Domains (2) summary
      smart00121
      Location:25 → 101
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:170 → 245
      Thyroglobulin_1; Thyroglobulin type-1 repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47879.2 GenPept UniProtKB/Swiss-Prot:P47879

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