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    Kif26b kinesin family member 26B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305012, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kif26bprovided by RGD
    Official Full Name
    kinesin family member 26Bprovided by RGD
    Primary source
    RGD:1560022
    See related
    Ensembl:ENSRNOG00000028624 AllianceGenome:RGD:1560022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560022; RGD1560572
    Summary
    Predicted to enable microtubule binding activity and microtubule motor activity. Predicted to act upstream of or within establishment of cell polarity; positive regulation of cell-cell adhesion; and ureteric bud invasion. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Orthologous to human KIF26B (kinesin family member 26B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 43.3), Kidney (RPKM 20.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q26
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (92815427..93221071)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (90282821..90689058)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (96775356..97173469, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene EF-hand calcium binding domain 2 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 1 Neighboring gene uncharacterized LOC134481603 Neighboring gene uncharacterized LOC134481536 Neighboring gene uncharacterized LOC134481605 Neighboring gene uncharacterized LOC134481604 Neighboring gene uncharacterized LOC108352580 Neighboring gene uncharacterized LOC108352579 Neighboring gene SET and MYND domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An enhancer-trap LacZ transgene reveals a distinct expression pattern of Kinesin family 26B in mouse embryos. Marikawa Y, et al. Dev Genes Evol, 2004 Feb. PMID 14727108
    2. Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme. Uchiyama Y, et al. Proc Natl Acad Sci U S A, 2010 May 18. PMID 20439720, Free PMC Article
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression analysis of a related gene in mouse.
      Title: An enhancer-trap LacZ transgene reveals a distinct expression pattern of Kinesin family 26B in mouse embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ureteric bud invasion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF26B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109079.3 → NP_001102549.2  kinesin-like protein KIF26B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      D4ADC4
      Related
      ENSRNOP00000017784.6, ENSRNOT00000017784.7
      Conserved Domains (2) summary
      smart00129
      Location:451 → 798
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00106
      Location:450 → 798
      KISc; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      92815427..93221071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272386.1 → XP_063128456.1  kinesin-like protein KIF26B isoform X1

    2. XM_063272387.1 → XP_063128457.1  kinesin-like protein KIF26B isoform X2

    3. XM_063272388.1 → XP_063128458.1  kinesin-like protein KIF26B isoform X2

    4. XM_039090818.2 → XP_038946746.1  kinesin-like protein KIF26B isoform X3

      UniProtKB/TrEMBL
      A6JGF1
      Conserved Domains (2) summary
      PHA03307
      Location:1319 → 1610
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00106
      Location:68 → 416
      KISc; Kinesin motor domain
    Nucleotide Protein Strain
    Heading Accession and Version

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