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    Slc25a14 solute carrier family 25 member 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85263, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Slc25a14provided by RGD
    Official Full Name
    solute carrier family 25 member 14provided by RGD
    Primary source
    RGD:621433
    See related
    Ensembl:ENSRNOG00000006871 AllianceGenome:RGD:621433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bmcp1
    Summary
    Predicted to enable C4-dicarboxylate transmembrane transporter activity; antiporter activity; and sulfur compound transmembrane transporter activity. Predicted to be involved in anion transport. Predicted to be located in mitochondrial envelope. Orthologous to human SLC25A14 (solute carrier family 25 member 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 63.4), Thymus (RPKM 30.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    Xq36
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (132685518..132723705)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (127807630..127845823)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (135470855..135509223)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene apoptosis inducing factor, mitochondria associated 1 Neighboring gene RAB33A, member RAS oncogene family Neighboring gene zinc finger protein 280C Neighboring gene G protein-coupled receptor 119 Neighboring gene RNA binding motif protein, X-linked 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Developmental programming by high fructose decreases phosphorylation efficiency in aging offspring brain mitochondria, correlating with enhanced UCP5 expression. Mortensen OH, et al. J Cereb Blood Flow Metab, 2014 Jul. PMID 24756078, Free PMC Article
    2. Molecular cloning of rat brain mitochondrial carrier protein-1 cDNA and its up-regulation during postnatal development. Kondou S, et al. Biochim Biophys Acta, 2000 Apr 21. PMID 10773163
    3. Maternal fructose-induced oxidative stress occurs viaTfam and Ucp5 epigenetic regulation in offspring hippocampi. Yamada H, et al. FASEB J, 2019 Oct. PMID 31314594
    4. Sex-dependent differences in aged rat brain mitochondrial function and oxidative stress. Guevara R, et al. Free Radic Biol Med, 2009 Jan 15. PMID 18992805
    5. Distinct regulation of brain mitochondrial carrier protein-1 and uncoupling protein-2 genes in the rat brain during cold exposure and aging. Mizuno T, et al. Biochem Biophys Res Commun, 2000 Nov 30. PMID 11095970

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Specificity protein 1 binding to the Ucp5 promoter regions was reduced by DNA methylation.
      Title: Maternal fructose-induced oxidative stress occurs viaTfam and Ucp5 epigenetic regulation in offspring hippocampi.
    2. maternal high-fructose diet during gestation and lactation has long-term effects (fetal programming) on brain mitochondrial function in aging rats, which appears to be linked to an increase in UCP5 protein levels.
      Title: Developmental programming by high fructose decreases phosphorylation efficiency in aging offspring brain mitochondria, correlating with enhanced UCP5 expression.
    3. expression levels are higher in aged female brain as compared to male one
      Title: Sex-dependent differences in aged rat brain mitochondrial function and oxidative stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables solute:inorganic anion antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inorganic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    brain mitochondrial carrier protein 1
    Names
    solute carrier family 25 (mitochondrial carrier, brain), member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053501.3 → NP_445953.1  brain mitochondrial carrier protein 1 precursor

      See identical proteins and their annotated locations for NP_445953.1

      Status: VALIDATED

      Source sequence(s)
      AF300424, JAXUCZ010000021
      UniProtKB/TrEMBL
      Q791E0, Q9EP88
      Conserved Domains (2) summary
      PTZ00169
      Location:44 → 323
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:234 → 323
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      132685518..132723705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257531.5 → XP_006257593.1  brain mitochondrial carrier protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A296
      Related
      ENSRNOP00000086458.1
      Conserved Domains (2) summary
      PTZ00169
      Location:63 → 342
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:253 → 342
      Mito_carr; Mitochondrial carrier protein

    2. XM_006257532.4 → XP_006257594.1  brain mitochondrial carrier protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006257594.1

      UniProtKB/TrEMBL
      Q9JMH0
      Related
      ENSRNOP00000009637.5
      Conserved Domains (2) summary
      PTZ00169
      Location:41 → 320
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:231 → 320
      Mito_carr; Mitochondrial carrier protein

    3. XM_006257535.3 → XP_006257597.1  brain mitochondrial carrier protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006257597.1

      Conserved Domains (2) summary
      PTZ00169
      Location:9 → 288
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:199 → 288
      Mito_carr; Mitochondrial carrier protein

    4. XM_008773531.4 → XP_008771753.1  brain mitochondrial carrier protein 1 isoform X3

      See identical proteins and their annotated locations for XP_008771753.1

      Conserved Domains (2) summary
      PTZ00169
      Location:9 → 288
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:199 → 288
      Mito_carr; Mitochondrial carrier protein

    5. XM_039100123.2 → XP_038956051.1  brain mitochondrial carrier protein 1 isoform X3

      Conserved Domains (2) summary
      PTZ00169
      Location:9 → 288
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:199 → 288
      Mito_carr; Mitochondrial carrier protein

    6. XM_039100125.2 → XP_038956053.1  brain mitochondrial carrier protein 1 isoform X5

      Conserved Domains (1) summary
      pfam00153
      Location:90 → 179
      Mito_carr; Mitochondrial carrier protein

    7. XM_039100124.2 → XP_038956052.1  brain mitochondrial carrier protein 1 isoform X4

    RNA

    1. XR_010061260.1 RNA Sequence

    2. XR_005498077.2 RNA Sequence

    3. XR_005498078.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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