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    Cfap69 cilia and flagella associated protein 69 [ Mus musculus (house mouse) ]

    Gene ID: 207686, updated on 5-Mar-2024

    Summary

    Official Symbol
    Cfap69provided by MGI
    Official Full Name
    cilia and flagella associated protein 69provided by MGI
    Primary source
    MGI:MGI:2443778
    See related
    Ensembl:ENSMUSG00000040473 AllianceGenome:MGI:2443778
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921525K03; A330021E22Rik
    Summary
    Involved in several processes, including positive regulation of fertilization; positive regulation of flagellated sperm motility; and response to odorant. Acts upstream of or within sperm axoneme assembly. Located in non-motile cilium. Is expressed in several structures, including brain; genitourinary system; gut gland; nasal cavity epithelium; and spinal cord ventricular layer. Used to study spermatogenic failure 24. Human ortholog(s) of this gene implicated in spermatogenic failure 24. Orthologous to human CFAP69 (cilia and flagella associated protein 69). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 13.1), frontal lobe adult (RPKM 3.0) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    5 A1; 5 3.07 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (5629284..5714232, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (5579278..5664232, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene GTP-binding protein 10 (putative) Neighboring gene family with sequence similarity 237, member B Neighboring gene predicted gene, 40262 Neighboring gene six transmembrane epithelial antigen of prostate 2 Neighboring gene STARR-seq mESC enhancer starr_12346 Neighboring gene STARR-seq mESC enhancer starr_12348 Neighboring gene STARR-seq mESC enhancer starr_12350 Neighboring gene STARR-seq mESC enhancer starr_12351 Neighboring gene six transmembrane epithelial antigen of the prostate 1 Neighboring gene predicted gene, 46900

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in olfactory behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fertilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to odorant IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to odorant IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axonemal central pair projection ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in non-motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in sperm midpiece IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cilia- and flagella-associated protein 69

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172447.2NP_766035.1  cilia- and flagella-associated protein 69

      See identical proteins and their annotated locations for NP_766035.1

      Status: PROVISIONAL

      Source sequence(s)
      AK039313
      Consensus CDS
      CCDS19075.1
      UniProtKB/Swiss-Prot
      Q3TPR3, Q8BH53, Q8CA81, Q8CDU8
      UniProtKB/TrEMBL
      A0A0G2JG21
      Related
      ENSMUSP00000053206.7, ENSMUST00000054865.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      5629284..5714232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503560.5XP_006503623.1  cilia- and flagella-associated protein 69 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JG21
    2. XM_011240666.2XP_011238968.1  cilia- and flagella-associated protein 69 isoform X2

      See identical proteins and their annotated locations for XP_011238968.1