Ccl27a C-C motif chemokine ligand 27A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccl27aprovided by MGI
Official Full Name: C-C motif chemokine ligand 27Aprovided by MGI
Primary source: MGI:MGI:1343459
See related: Ensembl:ENSMUSG00000073888 AllianceGenome:MGI:1343459
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ALP; ILC; CTAK; CTACK; Ccl27; PESKY; ESkine; Scya27; Scya27a
Summary: Enables chemokine activity. Involved in cell chemotaxis. Acts upstream of or within positive regulation of T cell chemotaxis and positive regulation of actin cytoskeleton reorganization. Located in extracellular region and nucleus. Is expressed in several structures, including genitourinary system; hip; liver; sensory organ; and skeleton. Orthologous to human CCL27 (C-C motif chemokine ligand 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 85.9), cortex adult (RPKM 62.4) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 22.08 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (41769467..41774251, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (41769467..41774225, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that losartan and dexamethasone may suppress inflammatory responses in IgA nephropathy by inhibiting CCL27 expression in Th22 cells
Title: Losartan and Dexamethasone may inhibit chemotaxis to reduce the infiltration of Th22 cells in IgA nephropathy.
Our in vivo analysis demonstrated that uniform expression of Ccr10 on MSCs and alteration of Ccl27 level in the skin enhance extravasation of stem cells from circulation and facilitate their migration within cutaneous tissue
Title: Analysis of chemotactic molecules in bone marrow-derived mesenchymal stem cells and the skin: Ccl27-Ccr10 axis as a basis for targeting to cutaneous tissues.
Results indicated that CCL27 modified inflammation by attracting CCR10-positive and CCR4-positive cells into the lesional skin, and may participate in the pathogenesis of Th2-shifted skin diseases such as atopic dermatitis.
Title: CCL27-transgenic mice show enhanced contact hypersensitivity to Th2, but not Th1 stimuli.
In mice, neutralization of CCL27 led to decreased leukocyte recruitment to cutaneous tumor sites and significantly enhanced primary tumor growth.
Title: Tumor immune escape by the loss of homeostatic chemokine expression.
We investigated the role of CCL27, a T cell skin-homing chemokine known to be elevated in sera of human AD patients, in disease development in our animal model of atopic dermatitis.
Title: CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model.
LIGHT stimulation enhances CCL27 expression through activation of NF-kappaB in DCs.
Title: TNF family molecule LIGHT regulates chemokine CCL27 expression on mouse embryonic stem cell-derived dendritic cells through NF-kappaB activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR3 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-C motif chemokine 27

Names: CC chemokine ILC; IL-11 R-alpha-locus chemokine; chemokine (C-C motif) ligand 27A; cutaneous T-cell-attracting chemokine; skinkine; skinskine; small inducible cytokine A27a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048179.2 → NP_001041644.1 C-C motif chemokine 27 isoform 1

See identical proteins and their annotated locations for NP_001041644.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL807796, BY294493, CA451425

Consensus CDS

CCDS38721.1

UniProtKB/TrEMBL

A2AMS7

Related

ENSMUSP00000103672.3, ENSMUST00000108037.9

Conserved Domains (1) summary

cl00134
Location:78 → 127

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...
NM_001164044.2 → NP_001157516.1 C-C motif chemokine 27 isoform 3

See identical proteins and their annotated locations for NP_001157516.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).

Source sequence(s)

AK005753, AL807796

Consensus CDS

CCDS51144.1

UniProtKB/TrEMBL

A2AMS8

Related

ENSMUSP00000103667.3, ENSMUST00000108032.3
NM_001164045.2 → NP_001157517.1 C-C motif chemokine 27 isoform 3

See identical proteins and their annotated locations for NP_001157517.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in both UTRs and the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).

Source sequence(s)

AL807796, BC099574

Consensus CDS

CCDS51144.1

UniProtKB/TrEMBL

A2AMS8

Related

ENSMUSP00000133827.2, ENSMUST00000173865.9
NM_001347065.1 → NP_001333994.1 C-C motif chemokine 27 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL807796

Consensus CDS

CCDS84714.1

UniProtKB/TrEMBL

A2AMS6

Conserved Domains (1) summary

cl00134
Location:41 → 90

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...
NM_001361246.1 → NP_001348175.1 C-C motif chemokine 27 isoform 1

Status: VALIDATED

Source sequence(s)

AL807796

Consensus CDS

CCDS38721.1

UniProtKB/TrEMBL

A2AMS7

Related

ENSMUSP00000103671.2, ENSMUST00000108036.8

Conserved Domains (1) summary

cl00134
Location:78 → 127

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...
NM_011336.2 → NP_035466.1 C-C motif chemokine 27 isoform 2 precursor

See identical proteins and their annotated locations for NP_035466.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' exon structure and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AB013398, CA451425

Consensus CDS

CCDS18072.1

UniProtKB/TrEMBL

A0A0R4J0X6, A2AMS5

Related

ENSMUSP00000073990.4, ENSMUST00000074387.4

Conserved Domains (1) summary

cl00134
Location:34 → 83

Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

RNA

NR_154591.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL807796

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

41769467..41774251 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253369.2 → XP_030109229.1 C-C motif chemokine 27 isoform X2

Conserved Domains (1) summary

pfam00048
Location:56 → 116

IL8; Small cytokines (intecrine/chemokine), interleukin-8 like
XM_011249967.4 → XP_011248269.1 C-C motif chemokine 27 isoform X1

See identical proteins and their annotated locations for XP_011248269.1

UniProtKB/TrEMBL

A2AMS7

Conserved Domains (1) summary

cl00134
Location:78 → 127

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...
XM_006537705.5 → XP_006537768.1 C-C motif chemokine 27 isoform X2

Conserved Domains (1) summary

pfam00048
Location:56 → 116

IL8; Small cytokines (intecrine/chemokine), interleukin-8 like
XM_006537704.4 → XP_006537767.1 C-C motif chemokine 27 isoform X1

See identical proteins and their annotated locations for XP_006537767.1

UniProtKB/TrEMBL

A2AMS7

Conserved Domains (1) summary

cl00134
Location:78 → 127

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...
XM_030253370.1 → XP_030109230.1 C-C motif chemokine 27 isoform X3

UniProtKB/TrEMBL

A2AMS6

Conserved Domains (1) summary

cl00134
Location:41 → 90

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...
XM_036163926.1 → XP_036019819.1 C-C motif chemokine 27 isoform X2

Conserved Domains (1) summary

pfam00048
Location:56 → 116

IL8; Small cytokines (intecrine/chemokine), interleukin-8 like
XM_006537706.5 → XP_006537769.1 C-C motif chemokine 27 isoform X3

See identical proteins and their annotated locations for XP_006537769.1

UniProtKB/TrEMBL

A2AMS6

Related

ENSMUSP00000103670.2, ENSMUST00000108035.8

Conserved Domains (1) summary

cl00134
Location:41 → 90

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...