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    Tpd52 tumor protein D52 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294900, updated on 27-Apr-2024

    Summary

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    Official Symbol
    Tpd52provided by RGD
    Official Full Name
    tumor protein D52provided by RGD
    Primary source
    RGD:1306767
    See related
    Ensembl:ENSRNOG00000011441 AllianceGenome:RGD:1306767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PrLZ; Crhsp-28
    Summary
    Predicted to enable calcium ion binding activity and protein homodimerization activity. Predicted to be involved in B cell differentiation. Predicted to act upstream of or within positive regulation of cell population proliferation. Predicted to be located in endoplasmic reticulum and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and glutamatergic synapse. Orthologous to human TPD52 (tumor protein D52). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 179.8), Brain (RPKM 154.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (94642514..94723442)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (92735365..92816079)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (94959732..95041277)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100771 Neighboring gene high mobility group protein B1-like Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene cytochrome c, somatic-like Neighboring gene uncharacterized protein C14orf119 homolog Neighboring gene small nucleolar RNA SNORA38

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells. Messenger SW, et al. Am J Physiol Gastrointest Liver Physiol, 2013 Sep 15. PMID 23868405, Free PMC Article
    2. Secretagogue-induced translocation of CRHSP-28 within an early apical endosomal compartment in acinar cells. Thomas DD, et al. Am J Physiol Gastrointest Liver Physiol, 2004 Jul. PMID 14977633
    3. Dietary and hormonal stimulation of rat exocrine pancreatic function regulates CRHSP-28 phosphorylation in vivo. Kaspar KM, et al. J Nutr, 2003 Oct. PMID 14519786
    4. Purification and identification of a 28-kDa calcium-regulated heat-stable protein. A novel secretagogue-regulated phosphoprotein in exocrine pancreas. Groblewski GE, et al. J Biol Chem, 1996 Dec 6. PMID 8940165
    5. Tumor protein D52 expression and Ca2+-dependent phosphorylation modulates lysosomal membrane protein trafficking to the plasma membrane. Thomas DD, et al. Am J Physiol Cell Physiol, 2010 Mar. PMID 20032513, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. binding of CRHSP-28 and annexin VI, together with their colocalization in the apical cytoplasm, is consistent with a role for these molecules in acinar cell membrane trafficking events that are essential for digestive enzyme secretion.
      Title: Identification of annexin VI as a Ca2+-sensitive CRHSP-28-binding protein in pancreatic acinar cells.
    2. data demonstrate that calcium-responsive heat stable protein-28(CRHSP-28 )phosphorylation occurs in vivo and can be used as a functional indicator of nutrient-driven pancreatic acinar cell activation
      Title: Dietary and hormonal stimulation of rat exocrine pancreatic function regulates CRHSP-28 phosphorylation in vivo.
    3. Calcium regulated heat stable protein-28 (CRHSP-28) accumulated on endosomes and positioned between zymogen granules below cell apex on CCK-8 stimulation. Present in acinar cells and regulated by secretagogue stimulation.
      Title: Secretagogue-induced translocation of CRHSP-28 within an early apical endosomal compartment in acinar cells.
    4. D52 regulates apical endolysosomal secretion in pancreatic acinar cells.
      Title: Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells.
    5. Implicate both D52 expression and Ca(2+)-dependent phosphorylation at serine 136 in lysosomal membrane trafficking to and from the plasma membrane providing a novel Ca(2+)-sensitive pathway modulating the lysosome-like secretory pathway.
      Title: Tumor protein D52 expression and Ca2+-dependent phosphorylation modulates lysosomal membrane protein trafficking to the plasma membrane.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tumor protein D52
    Names
    calcium regulated heat stable protein-28
    XP_006232205.3
    XP_008759084.3
    XP_038957892.2
    XP_063137606.1
    XP_063137607.1
    XP_063137608.1
    XP_063137609.1
    XP_063137610.1
    XP_063137611.1
    XP_063137612.1
    XP_063137613.1
    XP_063137614.1
    XP_063137615.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106421.3 → NP_001099891.3  tumor protein D52 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      Related
      ENSRNOP00000015327.6, ENSRNOT00000015327.7

    2. NM_001401807.2 → NP_001388736.2  tumor protein D52 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      Related
      ENSRNOP00000085840.1, ENSRNOT00000099506.1

    3. NM_001401808.2 → NP_001388737.2  tumor protein D52 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    4. NM_001429760.1 → NP_001416689.1  tumor protein D52 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    5. NM_001429761.1 → NP_001416690.1  tumor protein D52 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    6. NM_001429762.1 → NP_001416691.1  tumor protein D52 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    7. NM_001429763.1 → NP_001416692.1  tumor protein D52 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    8. NM_001429764.1 → NP_001416693.1  tumor protein D52 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    9. NM_001429765.1 → NP_001416694.1  tumor protein D52 isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      94642514..94723442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281536.1 → XP_063137606.1  tumor protein D52 isoform X1

    2. XM_063281538.1 → XP_063137608.1  tumor protein D52 isoform X3

    3. XM_063281537.1 → XP_063137607.1  tumor protein D52 isoform X2

    4. XM_063281539.1 → XP_063137609.1  tumor protein D52 isoform X4

    5. XM_063281541.1 → XP_063137611.1  tumor protein D52 isoform X6

    6. XM_063281540.1 → XP_063137610.1  tumor protein D52 isoform X5

    7. XM_063281544.1 → XP_063137614.1  tumor protein D52 isoform X12

    8. XM_063281545.1 → XP_063137615.1  tumor protein D52 isoform X13

    9. XM_063281543.1 → XP_063137613.1  tumor protein D52 isoform X11

    10. XM_063281542.1 → XP_063137612.1  tumor protein D52 isoform X7

    11. XM_006232143.5 → XP_006232205.3  tumor protein D52 isoform X8

    12. XM_039101964.2 → XP_038957892.2  tumor protein D52 isoform X10

    13. XM_008760862.4 → XP_008759084.3  tumor protein D52 isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version

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