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    Cpne5 copine 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309650, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Cpne5provided by RGD
    Official Full Name
    copine 5provided by RGD
    Primary source
    RGD:1308021
    See related
    Ensembl:ENSRNOG00000000522 AllianceGenome:RGD:1308021
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion and positive regulation of dendrite extension. Predicted to be located in neuron projection and neuronal cell body. Predicted to be active in plasma membrane. Orthologous to human CPNE5 (copine 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 32.3), Uterus (RPKM 5.5) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    20p12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7208389..7290959, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7206742..7289309, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6419033..6500843, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene RAB44, member RAS oncogene family Neighboring gene neuropeptides B and W receptor 1 like 1 Neighboring gene uncharacterized LOC134483865 Neighboring gene uncharacterized LOC102547155 Neighboring gene peptidylprolyl isomerase like 1 Neighboring gene transfer RNA threonine (anticodon AGU) 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IL-33, a potent inducer of adaptive immunity to intestinal nematodes. Humphreys NE, et al. J Immunol, 2008 Feb 15. PMID 18250453
    2. Localization and cellular distribution of CPNE5 in embryonic mouse brain. Ding X, et al. Brain Res, 2008 Aug 11. PMID 18614158
    3. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. Yoo JC, et al. J Dermatol Sci, 2013 Dec. PMID 23999003
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    copine-5
    Names
    copine 5 protein
    copine V

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107616.2 → NP_001101086.1  copine-5

      See identical proteins and their annotated locations for NP_001101086.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I5ZN81, A6JJU1, D3ZGN2
      Related
      ENSRNOP00000000629.3, ENSRNOT00000000629.5
      Conserved Domains (3) summary
      cd04047
      Location:177 → 288
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:23 → 137
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:298 → 554
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      7208389..7290959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601646.3 → XP_017457135.1  copine-5 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN81, A0A8I6A0U5
      Related
      ENSRNOP00000085748.1

    2. XM_017601647.3 → XP_017457136.1  copine-5 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZN81, A0A8I6AER2
      Related
      ENSRNOP00000090957.1

    3. XM_017601649.3 → XP_017457138.1  copine-5 isoform X5

    4. XM_063279146.1 → XP_063135216.1  copine-5 isoform X3

    5. XM_039098709.2 → XP_038954637.1  copine-5 isoform X4

      Conserved Domains (1) summary
      cd01459
      Location:17 → 271
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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