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    Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498690, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ctla2aprovided by RGD
    Official Full Name
    cytotoxic T lymphocyte-associated protein 2 alphaprovided by RGD
    Primary source
    RGD:1565540
    See related
    Ensembl:ENSRNOG00000039971 AllianceGenome:RGD:1565540
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565540
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to be active in extracellular space and lysosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 63.9), Thymus (RPKM 43.1) and 7 other tissues See more
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    Genomic context

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    Location:
    17p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (3809052..3828872)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (3803844..3805729)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (4169696..4194700)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene cathepsin M like 1 Neighboring gene trophoblast specific protein alpha Neighboring gene testin gene Neighboring gene thioredoxin-related transmembrane protein 3, pseudogene 1 Neighboring gene cathepsin L-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    protein CTLA-2-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109115.1 → NP_001102585.1  protein CTLA-2-alpha

      See identical proteins and their annotated locations for NP_001102585.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474032
      UniProtKB/TrEMBL
      A6KAE9, A6KAF1, D3ZHI6
      Related
      ENSRNOP00000058141.2, ENSRNOT00000061422.3
      Conserved Domains (1) summary
      smart00848
      Location:16 → 74
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      3809052..3828872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276680.1 → XP_063132750.1  protein CTLA-2-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANI3

    2. XM_063276681.1 → XP_063132751.1  protein CTLA-2-alpha isoform X2

      UniProtKB/TrEMBL
      A6KAE9, D3ZHI6
    Nucleotide Protein Strain
    Heading Accession and Version

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