ALAS1 5'-aminolevulinate synthase 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: ALAS1provided by CGNC
Full Name: 5'-aminolevulinate synthase 1provided by CGNC
Primary source: CGNC:2897
See related: Ensembl:ENSGALG00010027410
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: ALAS2; ALASE; ALASN; ALAS-E
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	12	NC_052543.1 (3121084..3127944)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	12	NC_052584.1 (3170637..3177489)

Chromosome 12 - NC_052543.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 5-aminolevulinate synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in erythrocyte development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heme biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hemoglobin biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5-aminolevulinate synthase, non-specific, mitochondrial; 5-aminolevulinate synthase, nonspecific, mitochondrial

Names: 5'-aminolevulinate synthase 2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial; 5-aminolevulinic acid synthase 1; 5-aminolevulinic acid synthase 2; ALA-synthase; ALAS-H; Delta-ALA synthase 2; Delta-aminolevulinate synthase 2; aminolevulinate, delta-, synthase 1; delta-ALA synthase 1; delta-aminolevulinate synthase 1

NP_001018012.2

EC 2.3.1.37

XP_025010275.1

EC 2.3.1.37

XP_046782444.1

EC 2.3.1.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001018012.2 → NP_001018012.2 5-aminolevulinate synthase, non-specific, mitochondrial precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000252

UniProtKB/Swiss-Prot

P07997

UniProtKB/TrEMBL

A0A1D5P0L4

Related

ENSGALP00010040723.1, ENSGALT00010066465.1

Conserved Domains (1) summary

cl18945
Location:192 → 597

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

3121084..3127944

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_025154507.2 → XP_025010275.1 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1

UniProtKB/Swiss-Prot

P07997

UniProtKB/TrEMBL

A0A8V1ABX4

Related

ENSGALP00010040722.1, ENSGALT00010066462.1

Conserved Domains (2) summary

pfam09029
Location:2 → 131

Preseq_ALAS; 5-aminolevulinate synthase presequence

cl18945
Location:140 → 545

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...