Hbb-b1 hemoglobin, beta adult major chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hbb-b1provided by RGD
Full Name: hemoglobin, beta adult major chainprovided by RGD
Primary source: RGD:1595848
See related: AllianceGenome:RGD:1595848
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Glna1
Summary: Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to be involved in oxygen transport. Predicted to be part of hemoglobin complex. Orthologous to human HBD (hemoglobin subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 79181.0), Lung (RPKM 19340.1) and 1 other tissue See more
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Genomic context

Location:: 1q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (167636064..167643577, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (158224175..158231675, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (168945531..168953023)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:531320

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:499134

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:259550

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in oxygen transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of hemoglobin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hemoglobin, beta adult major chain

Names: beta-glo; globin a1; hemoglobin beta-chain; hemoglobin subunit beta-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198776.2 → NP_942071.2 hemoglobin, beta adult major chain

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AUL4, Q62669

Conserved Domains (1) summary

cd08925
Location:8 → 146

Hb-beta-like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

167636064..167643577 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229913.5 → XP_006229975.3 hemoglobin, beta adult major chain isoform X1

Conserved Domains (1) summary

cl21461
Location:8 → 107

Globin-like; Globin-like protein superfamily