Exoc5 exocyst complex component 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Exoc5provided by RGD
Official Full Name: exocyst complex component 5provided by RGD
Primary source: RGD:708408
See related: Ensembl:ENSRNOG00000013804 AllianceGenome:RGD:708408
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sec10l1
Summary: Predicted to enable protein N-terminus binding activity and small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane transport; exocytosis; and protein localization to plasma membrane. Predicted to act upstream of with a negative effect on epithelial cell apoptotic process. Predicted to act upstream of or within establishment of planar polarity and non-motile cilium assembly. Located in cytosol. Orthologous to human EXOC5 (exocyst complex component 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 220.6), Brain (RPKM 191.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (24788738..24834941, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (22310682..22355695, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (25888757..25933302, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heterozygous knockout of Exoc5 in skeletal myoblast cells leads to impaired GLUT4 trafficking to the plasma membrane and hinders glucose uptake in response to an insulin stimulus.
Title: The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_negative_effect epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of planar polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect establishment of planar polarity	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: exocyst complex component 5

Names: 71 kDa component of rsec6/8 secretory complex; SEC10-like 1; exocyst complex component Sec10; p71 component of rsec6/8 secretory complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022204.3 → NP_071540.1 exocyst complex component 5

See identical proteins and their annotated locations for NP_071540.1

Status: PROVISIONAL

Source sequence(s)

BC128739

UniProtKB/Swiss-Prot

A1A5N5, P97878

UniProtKB/TrEMBL

A0A8I5ZM73, A6KE83

Related

ENSRNOP00000062799.2, ENSRNOT00000067735.4

Conserved Domains (1) summary

pfam07393
Location:89 → 707

Sec10; Exocyst complex component Sec10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

24788738..24834941 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093635.2 → XP_038949563.1 exocyst complex component 5 isoform X1

UniProtKB/TrEMBL

A0A8I5ZM73

Conserved Domains (1) summary

pfam07393
Location:10 → 561

Sec10; Exocyst complex component Sec10
XM_063274610.1 → XP_063130680.1 exocyst complex component 5 isoform X2