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    Dad1 defender against cell death 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192275, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Dad1provided by RGD
    Official Full Name
    defender against cell death 1provided by RGD
    Primary source
    RGD:621028
    See related
    Ensembl:ENSRNOG00000009090 AllianceGenome:RGD:621028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme activator activity. Involved in response to nutrient and response to xenobiotic stimulus. Predicted to be integral component of membrane. Predicted to be part of oligosaccharyltransferase complex. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 271.8), Kidney (RPKM 261.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    15p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (31647326..31667159, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (27677286..27697120, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (32868136..32887933, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene T cell receptor delta constant like Neighboring gene T-cell receptor alpha chain V region Neighboring gene abhydrolase domain containing 4, N-acyl phospholipase B Neighboring gene uncharacterized LOC134482120

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone. Rosen MB, et al. Reprod Toxicol, 2005 Jan-Feb. PMID 15686871
    2. Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Fischer A, et al. Biochem Biophys Res Commun, 2001 Jul 13. PMID 11444866
    3. Deletion of Dad1 in mice induces an apoptosis-associated embryonic death. Brewster JL, et al. Genesis, 2000 Apr. PMID 10748466
    4. The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation. Roboti P, et al. J Cell Sci, 2012 Jul 15. PMID 22467853
    5. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. Kelleher DJ, et al. Mol Cell, 2003 Jul. PMID 12887896

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blastocyst development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oligosaccharyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
    Names
    DAD-1
    oligosaccharyl transferase subunit DAD1
    NP_001380736.1
    NP_620265.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393807.1 → NP_001380736.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8L2Q6I7
      Related
      ENSRNOP00000012233.3, ENSRNOT00000012233.6
      Conserved Domains (1) summary
      pfam02109
      Location:7 → 130
      DAD; DAD family

    2. NM_138910.4 → NP_620265.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 isoform 2

      See identical proteins and their annotated locations for NP_620265.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P61805
      UniProtKB/TrEMBL
      A6KGR8
      Related
      ENSRNOP00000092852.1, ENSRNOT00000098684.1
      Conserved Domains (1) summary
      pfam02109
      Location:7 → 113
      DAD; DAD family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      31647326..31667159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61805.3 GenPept UniProtKB/Swiss-Prot:P61805

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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