Hbp1 high mobility group box transcription factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hbp1provided by MGI
Official Full Name: high mobility group box transcription factor 1provided by MGI
Primary source: MGI:MGI:894659
See related: Ensembl:ENSMUSG00000002996 AllianceGenome:MGI:894659
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700058O05Rik; C330012F01Rik
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of lipid transport and negative regulation of reactive oxygen species biosynthetic process. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and neural retina. Orthologous to human HBP1 (HMG-box transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in mammary gland adult (RPKM 23.0), ovary adult (RPKM 22.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A3; 12 13.73 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (31976449..32000529, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (31926452..31950530, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-103a-3p promotes inflammation and fibrosis in nonalcoholic fatty liver disease by targeting HBP1.
Title: microRNA-103a-3p promotes inflammation and fibrosis in nonalcoholic fatty liver disease by targeting HBP1.
HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene.
Title: HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene.
HBP1 knockdown leads to a significant reduction of C/EBPa expression, suggesting that HBP1-mediated C/EBPa expression may be needed for the termination of the cell cycle at the end of MCE for terminal differentiation
Title: Transcription factor HMG box-containing protein 1 (HBP1) modulates mitotic clonal expansion (MCE) during adipocyte differentiation.
the regulation of Hbp1 conferred substantial protection of ovarian reserve.
Title: Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve.
new regulatory pathway of YY1/HDACs/miR-155/HBP1 in macrophage-derived foam cell formation during early atherogenesis
Title: Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis.
identify the high-mobility group box protein HBP1 transcriptional repressor as a new substrate for p38 MAP kinase
Title: The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation.
Hbp1 is up-regulated specifically in germ cells of the developing XY gonad
Title: HMG box transcription factor gene Hbp1 is expressed in germ cells of the developing mouse testis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Gene trapped (2)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hbp1 (e-PCR), detects polymorphism
- UniSTS:527383

NoName (e-PCR)
- UniSTS:236826

NoName (e-PCR)
- UniSTS:236827

Hbp1 (e-PCR), detects polymorphism
- UniSTS:461895

BE629963 (e-PCR)
- UniSTS:208789

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of macrophage derived foam cell differentiation	IC Inferred by Curator more info	PubMed
involved_in negative regulation of reactive oxygen species biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: HMG box-containing protein 1

Names: HMG box transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361928.1 → NP_001348857.1 HMG box-containing protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

CT010463

UniProtKB/Swiss-Prot

Q3V0I4, Q8BUS3, Q8C199, Q8R316

UniProtKB/TrEMBL

Q3UTR1

Conserved Domains (2) summary

smart00536
Location:214 → 340

AXH; domain in Ataxins and HMG containing proteins

cd01388
Location:435 → 506

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
NM_153198.3 → NP_694878.2 HMG box-containing protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK132503, AK133127, CT010463

Consensus CDS

CCDS25867.2

UniProtKB/TrEMBL

E9Q1A8, Q3UTR1

Related

ENSMUSP00000131158.3, ENSMUST00000172314.9

Conserved Domains (2) summary

smart00536
Location:224 → 350

AXH; domain in Ataxins and HMG containing proteins

cd01388
Location:445 → 516

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_177993.4 → NP_818774.2 HMG box-containing protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter C-terminus, compared to isoform 1.

Source sequence(s)

AK028674, AK133127

Consensus CDS

CCDS25868.2

UniProtKB/TrEMBL

E9Q469, Q3UQS1

Related

ENSMUSP00000131983.3, ENSMUST00000167458.9

Conserved Domains (2) summary

smart00536
Location:224 → 350

AXH; domain in Ataxins and HMG containing proteins

cl00082
Location:445 → 474

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

31976449..32000529 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157627.1 → XP_036013520.1 HMG box-containing protein 1 isoform X5

UniProtKB/TrEMBL

Q3UTR1

Conserved Domains (2) summary

cd01388
Location:370 → 441

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08517
Location:190 → 272

AXH; Ataxin-1 and HBP1 module (AXH)
XM_030246951.2 → XP_030102811.1 HMG box-containing protein 1 isoform X3

UniProtKB/Swiss-Prot

Q3V0I4, Q8BUS3, Q8C199, Q8R316

UniProtKB/TrEMBL

Q3UTR1

Conserved Domains (2) summary

smart00536
Location:214 → 340

AXH; domain in Ataxins and HMG containing proteins

cd01388
Location:435 → 506

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036157626.1 → XP_036013519.1 HMG box-containing protein 1 isoform X4

UniProtKB/TrEMBL

Q3UTR1

Conserved Domains (2) summary

cd01388
Location:370 → 441

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08517
Location:190 → 272

AXH; Ataxin-1 and HBP1 module (AXH)
XM_006515227.4 → XP_006515290.1 HMG box-containing protein 1 isoform X1

UniProtKB/TrEMBL

Q3UTR1

Conserved Domains (2) summary

smart00536
Location:224 → 350

AXH; domain in Ataxins and HMG containing proteins

cd01388
Location:445 → 516

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006515229.5 → XP_006515292.1 HMG box-containing protein 1 isoform X2

See identical proteins and their annotated locations for XP_006515292.1

UniProtKB/TrEMBL

Q3UTR1

Conserved Domains (2) summary

smart00536
Location:214 → 340

AXH; domain in Ataxins and HMG containing proteins

cd01388
Location:435 → 506

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006515228.5 → XP_006515291.1 HMG box-containing protein 1 isoform X2

See identical proteins and their annotated locations for XP_006515291.1

UniProtKB/TrEMBL

Q3UTR1

Conserved Domains (2) summary

smart00536
Location:214 → 340

AXH; domain in Ataxins and HMG containing proteins

cd01388
Location:435 → 506

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...