Ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddostprovided by RGD
Official Full Name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunitprovided by RGD
Primary source: RGD:1308970
See related: Ensembl:ENSRNOG00000015079 AllianceGenome:RGD:1308970
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme activator activity. Predicted to be involved in several processes, including T cell activation; protein N-linked glycosylation via asparagine; and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ir. Orthologous to human DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 494.1), Liver (RPKM 389.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (155805612..155812728)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (150522297..150529413)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (156668924..156676036)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest expression of Rage (advanced glycosylation end product-specific receptor) and Ager1/Ddost can be altered by dietary factors; diet high in AGE (advanced glycation end products) up-regulates expression of Rage and Ager1/Ddost after 2 weeks.
Title: Short-term effects of dietary advanced glycation end products in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132329 (e-PCR)
- UniSTS:215612

RH130187 (e-PCR)
- UniSTS:213474

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation via asparagine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation via asparagine	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation via asparagine	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of oligosaccharyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of oligosaccharyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of oligosaccharyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

Names: DDOST 48 kDa subunit; dolichyl-di-phosphooligosaccharide-protein glycotransferase; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic); dolichyl-diphosphooligosaccharide-protein glycosyltransferase; oligosaccharyl transferase 48 kDa subunit

NP_001012104.1

EC 2.4.99.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012104.1 → NP_001012104.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor

See identical proteins and their annotated locations for NP_001012104.1

Status: PROVISIONAL

Source sequence(s)

BC082075

UniProtKB/Swiss-Prot

Q641Y0

UniProtKB/TrEMBL

A6ITG9

Related

ENSRNOP00000062365.4, ENSRNOT00000067228.4

Conserved Domains (1) summary

pfam03345
Location:32 → 440

DDOST_48kD; Oligosaccharyltransferase 48 kDa subunit beta