Myl9 myosin light chain 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myl9provided by RGD
Official Full Name: myosin light chain 9provided by RGD
Primary source: RGD:1311235
See related: Ensembl:ENSRNOG00000020246 AllianceGenome:RGD:1311235
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable myosin heavy chain binding activity. Predicted to be involved in platelet aggregation. Predicted to be located in Z disc and stress fiber. Predicted to be part of myosin II complex. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human MYL9 (myosin light chain 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 1884.6), Heart (RPKM 1193.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (165742020..165748409)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (145281943..145288333)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (152857573..152863961)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

consistent upregulation of the myosin light chain protein (Myl9) with age and injury
Title: Dynamic regulation of vascular myosin light chain (MYL9) with injury and aging.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140697 (e-PCR)
- UniSTS:222764

RH140996 (e-PCR)
- UniSTS:222764

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables myosin heavy chain binding	IEA Inferred from Electronic Annotation more info
enables myosin heavy chain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in myofibril assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	ISO Inferred from Sequence Orthology more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin regulatory light polypeptide 9

Names: myosin regulatory light chain 9; myosin, light chain 9, regulatory; myosin, light polypeptide 9, regulatory

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100885.3 → NP_001094355.2 myosin regulatory light polypeptide 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q64122

UniProtKB/TrEMBL

B0BMS8, F7F3J1

Conserved Domains (1) summary

COG5126
Location:19 → 169

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001430178.1 → NP_001417107.1 myosin regulatory light polypeptide 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

165742020..165748409

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235402.4 → XP_006235464.1 myosin regulatory light polypeptide 9 isoform X1

UniProtKB/Swiss-Prot

Q64122

UniProtKB/TrEMBL

B0BMS8, F7F3J1

Related

ENSRNOP00000027445.5, ENSRNOT00000027445.8

Conserved Domains (1) summary

COG5126
Location:19 → 169

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]