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    Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361063, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Entpd4provided by RGD
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 4provided by RGD
    Primary source
    RGD:1309511
    See related
    Ensembl:ENSRNOG00000016321 AllianceGenome:RGD:1309511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable pyrophosphatase activity. Predicted to be involved in nucleobase-containing small molecule metabolic process. Predicted to be located in Golgi membrane and autophagosome membrane. Predicted to be integral component of Golgi membrane and integral component of autophagosome membrane. Predicted to be active in Golgi apparatus and membrane. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 264.8), Adrenal (RPKM 230.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51040665..51068450)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (44630878..44658654)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (51222954..51250787)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene syncytin b Neighboring gene Set nuclear proto-oncogene, pseudogene 13 Neighboring gene lysyl oxidase-like 2 Neighboring gene R3H domain and coiled-coil containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles. Biederbick A, et al. J Cell Sci, 1999 Aug. PMID 10393803
    2. Golgi localization and functional expression of human uridine diphosphatase. Wang TF, et al. J Biol Chem, 1998 May 1. PMID 9556635
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CTP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleobase-containing small molecule catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 4
    NP_001388593.1
    NP_001388594.1
    XP_006252338.1
    XP_063130500.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401664.1 → NP_001388593.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HTH4

    2. NM_001401665.1 → NP_001388594.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2JX61
      Related
      ENSRNOP00000070148.2, ENSRNOT00000088928.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      51040665..51068450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274430.1 → XP_063130500.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX61

    2. XM_006252276.5 → XP_006252338.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1

      See identical proteins and their annotated locations for XP_006252338.1

      UniProtKB/TrEMBL
      A6HTH4
      Conserved Domains (1) summary
      cl17037
      Location:82 → 540
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108384.1: Suppressed sequence

      Description
      NM_001108384.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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