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    Dnttip1 deoxynucleotidyltransferase, terminal, interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171437, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dnttip1provided by RGD
    Official Full Name
    deoxynucleotidyltransferase, terminal, interacting protein 1provided by RGD
    Primary source
    RGD:621627
    See related
    Ensembl:ENSRNOG00000014933 AllianceGenome:RGD:621627
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity; nucleosome binding activity; and protein homodimerization activity. Predicted to be located in chromosome; nucleolus; and nucleoplasm. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Orthologous to human DNTTIP1 (deoxynucleotidyltransferase terminal interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 92.6), Testes (RPKM 78.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q42
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173901070..173924742)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153481718..153505403)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161212156..161235749)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L13 pseudogene Neighboring gene WAP four-disulfide core domain 3 Neighboring gene ubiquitin-conjugating enzyme E2C Neighboring gene troponin C2, fast skeletal type

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The oncofetal protein p65: a new member of the steroid/thyroid receptor superfamily. Hanausek M, et al. Cancer Detect Prev, 1996. PMID 8706045
    2. Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting. Itoh T, et al. Nucleic Acids Res, 2015 Feb 27. PMID 25653165, Free PMC Article
    3. Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. Yamashita N, et al. Genes Cells, 2001 Jul. PMID 11473582
    4. Direct binding of TReP-132 with TdT results in reduction of TdT activity. Fujisaki S, et al. Genes Cells, 2006 Jan. PMID 16371131
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124886

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone deacetylase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone deacetylase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    deoxynucleotidyltransferase terminal-interacting protein 1
    Names
    tdIF1
    tdT-interacting factor 1
    terminal deoxynucleotidyltransferase-interacting factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134400.2 → NP_599227.2  deoxynucleotidyltransferase terminal-interacting protein 1

      See identical proteins and their annotated locations for NP_599227.2

      Status: VALIDATED

      Source sequence(s)
      BC100640
      UniProtKB/Swiss-Prot
      Q91Y53
      UniProtKB/TrEMBL
      Q497A7
      Related
      ENSRNOP00000020280.5, ENSRNOT00000020280.6
      Conserved Domains (1) summary
      pfam18192
      Location:65 → 132
      DNTTIP1_dimer; DNTTIP1 dimerisation domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173901070..173924742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104212.2 → XP_038960140.1  deoxynucleotidyltransferase terminal-interacting protein 1 isoform X3

      Conserved Domains (1) summary
      pfam18192
      Location:65 → 125
      DNTTIP1_dimer; DNTTIP1 dimerisation domain

    2. XM_039104210.2 → XP_038960138.1  deoxynucleotidyltransferase terminal-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q91Y53
      Conserved Domains (1) summary
      pfam18192
      Location:65 → 132
      DNTTIP1_dimer; DNTTIP1 dimerisation domain

    3. XM_039104211.2 → XP_038960139.1  deoxynucleotidyltransferase terminal-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q91Y53
      Conserved Domains (1) summary
      pfam18192
      Location:25 → 92
      DNTTIP1_dimer; DNTTIP1 dimerisation domain

    RNA

    1. XR_005501766.2 RNA Sequence

    2. XR_005501767.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Y53.1 GenPept UniProtKB/Swiss-Prot:Q91Y53

    Gene LinkOut

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