Epha8 Eph receptor A8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Epha8provided by RGD
Official Full Name: Eph receptor A8provided by RGD
Primary source: RGD:708543
See related: Ensembl:ENSRNOG00000013036 AllianceGenome:RGD:708543
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GPI-linked ephrin receptor activity; growth factor binding activity; and transmembrane-ephrin receptor activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; neuron development; and positive regulation of phosphatidylinositol 3-kinase activity. Predicted to act upstream of or within cellular response to follicle-stimulating hormone stimulus. Predicted to be located in early endosome membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human EPHA8 (EPH receptor A8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 14.2), Testes (RPKM 2.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (154449566..154476966, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (149166107..149193515, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (155293731..155321016, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Epha4 (e-PCR), detects polymorphism
- UniSTS:266987

AW047546 (e-PCR)
- UniSTS:165365

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables GPI-linked ephrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables ephrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to follicle-stimulating hormone stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron remodeling	IEA Inferred from Electronic Annotation more info
involved_in neuron remodeling	ISO Inferred from Sequence Orthology more info
involved_in neuron remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in substrate-dependent cell migration	IEA Inferred from Electronic Annotation more info
involved_in substrate-dependent cell migration	ISO Inferred from Sequence Orthology more info
involved_in substrate-dependent cell migration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ephrin type-A receptor 8

Names: EPH- and ELK-related kinase; tyrosine-protein kinase receptor EEK

NP_001406194.1

EC 2.7.10.1

XP_008762544.2

EC 2.7.10.1

XP_063144406.1

EC 2.7.10.1

XP_063144407.1

EC 2.7.10.1

XP_063144408.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419265.2 → NP_001406194.1 ephrin type-A receptor 8 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

F1LMX3

Related

ENSRNOP00000017559.5, ENSRNOT00000017559.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

154449566..154476966 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008764322.3 → XP_008762544.2 ephrin type-A receptor 8 isoform X1

UniProtKB/TrEMBL

A6ITC7

Conserved Domains (5) summary

cd09550
Location:858 → 920

SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors

cd00063
Location:365 → 456

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:255 → 348

fn3; Fibronectin type III domain

cl02704
Location:1 → 128

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

cl21453
Location:555 → 821

PKc_like; Protein Kinases, catalytic domain
XM_063288336.1 → XP_063144406.1 ephrin type-A receptor 8 isoform X2
XM_063288337.1 → XP_063144407.1 ephrin type-A receptor 8 isoform X3
XM_063288338.1 → XP_063144408.1 ephrin type-A receptor 8 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001191870.1: Suppressed sequence

Description

NM_001191870.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.