Stard7 StAR-related lipid transfer domain containing 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stard7provided by RGD
Official Full Name: StAR-related lipid transfer domain containing 7provided by RGD
Primary source: RGD:1307613
See related: Ensembl:ENSRNOG00000013479 AllianceGenome:RGD:1307613
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable lipid binding activity. Predicted to act upstream of or within several processes, including establishment of skin barrier; mucociliary clearance; and myeloid dendritic cell activation. Predicted to be located in cytoplasm and extracellular region. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 2. Orthologous to human STARD7 (StAR related lipid transfer domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 279.1), Heart (RPKM 262.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (134935602..134969140)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (114487161..114515828)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (119698655..119727303)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that StarD7 facilitates the delivery of phosphatidylcholine to mitochondria in non-vesicular system.
Title: StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131518 (e-PCR)
- UniSTS:214801

D11Mit209 (e-PCR), detects polymorphism
- UniSTS:126411

RH127881 (e-PCR)
- UniSTS:211191

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within establishment of skin barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mucociliary clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid dendritic cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within type 2 immune response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stAR-related lipid transfer protein 7, mitochondrial

Names: START domain containing 7; StAR-related lipid transfer (START) domain containing 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399278.1 → NP_001386207.1 stAR-related lipid transfer protein 7, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6ATX5

Related

ENSRNOP00000097118.1, ENSRNOT00000095321.1

Conserved Domains (1) summary

cd08911
Location:121 → 328

START_STARD7-like; Lipid-binding START domain of mammalian STARD7 and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

134935602..134969140

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283329.1 → XP_063139399.1 stAR-related lipid transfer protein 7, mitochondrial isoform X1

RNA

XR_010064580.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106503.1: Suppressed sequence

Description

NM_001106503.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.