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    Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295690, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dnajc10provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C10provided by RGD
    Primary source
    RGD:1307813
    See related
    Ensembl:ENSRNOG00000006803 AllianceGenome:RGD:1307813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATPase binding activity; Hsp70 protein binding activity; and oxidoreductase activity, acting on a sulfur group of donors. Predicted to be involved in several processes, including positive regulation of ATPase activity; protein folding in endoplasmic reticulum; and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum lumen. Predicted to be part of endoplasmic reticulum chaperone complex. Orthologous to human DNAJC10 (DnaJ heat shock protein family (Hsp40) member C10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 337.6), Brain (RPKM 285.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q24
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (85636890..85679620)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (65232031..65272732)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (67538289..67578308)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 1A Neighboring gene uncharacterized LOC134486399 Neighboring gene uncharacterized LOC103691836 Neighboring gene uncharacterized LOC134486398 Neighboring gene frizzled-related protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ERdj5 sensitizes neuroblastoma cells to endoplasmic reticulum stress-induced apoptosis. Thomas CG, et al. J Biol Chem, 2009 Mar 6. PMID 19122239
    2. ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor. Oka OB, et al. Mol Cell, 2013 Jun 27. PMID 23769672, Free PMC Article
    3. ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER. Ushioda R, et al. Science, 2008 Jul 25. PMID 18653895
    4. Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5. Hagiwara M, et al. Mol Cell, 2011 Feb 18. PMID 21329881
    5. JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs. Hosoda A, et al. J Biol Chem, 2003 Jan 24. PMID 12446677

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables disulfide oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables misfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-disulfide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in IRE1-mediated unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of endoplasmic reticulum chaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 10
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 10
    NP_001099956.2
    XP_038960426.1
    XP_063139350.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106486.2 → NP_001099956.2  dnaJ homolog subfamily C member 10 precursor

      See identical proteins and their annotated locations for NP_001099956.2

      Status: VALIDATED

      Source sequence(s)
      BC100105, CA338978, CA510153, CB577930, CX570839, DY315949
      UniProtKB/Swiss-Prot
      Q498R3
      UniProtKB/TrEMBL
      A0A8I5ZQ34
      Related
      ENSRNOP00000009839.4, ENSRNOT00000009839.5
      Conserved Domains (5) summary
      COG0484
      Location:34 → 132
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      cd03003
      Location:129 → 229
      PDI_a_ERdj5_N; PDIa family, N-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is comprised of the first TRX domain of ERdj5 located after the ...
      cd03004
      Location:556 → 663
      PDI_a_ERdj5_C; PDIa family, C-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is composed of the three TRX domains located at the C-terminal ...
      TIGR01130
      Location:130 → 551
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam00226
      Location:35 → 97
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      85636890..85679620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104498.2 → XP_038960426.1  dnaJ homolog subfamily C member 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQ34, A0A8I6AIP1
      Related
      ENSRNOP00000092816.1
      Conserved Domains (4) summary
      COG0484
      Location:34 → 132
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      cd03003
      Location:129 → 229
      PDI_a_ERdj5_N; PDIa family, N-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is comprised of the first TRX domain of ERdj5 located after the ...
      cd03004
      Location:556 → 663
      PDI_a_ERdj5_C; PDIa family, C-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is composed of the three TRX domains located at the C-terminal ...
      TIGR01130
      Location:130 → 551
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    2. XM_063283280.1 → XP_063139350.1  dnaJ homolog subfamily C member 10 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q498R3.2 GenPept UniProtKB/Swiss-Prot:Q498R3

    Gene LinkOut

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