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    Stk38l serine/threonine kinase 38 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691337, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Stk38lprovided by RGD
    Official Full Name
    serine/threonine kinase 38 likeprovided by RGD
    Primary source
    RGD:1564793
    See related
    Ensembl:ENSRNOG00000001828 AllianceGenome:RGD:1564793
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564793
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; peptidyl-serine phosphorylation; and regulation of cellular component organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in actin cytoskeleton and cytosol. Orthologous to human STK38L (serine/threonine kinase 38 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 85.4), Kidney (RPKM 73.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stk38l in Genome Data Viewer
    Location:
    4q44
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (181346969..181423844)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179616288..179693177)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (181027212..181089735)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transmembrane 7 superfamily member 3 Neighboring gene mediator complex subunit 21 Neighboring gene basic helix-loop-helix ARNT like 2 Neighboring gene single-pass membrane protein with coiled-coil domains 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors. Fuller SJ, et al. Cell Signal, 2008 Aug. PMID 18555663
    2. Neuronal functions of the novel serine/threonine kinase Ndr2. Stork O, et al. J Biol Chem, 2004 Oct 29. PMID 15308672
    3. Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. Stegert MR, et al. J Biol Chem, 2004 May 28. PMID 15037617
    4. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. Devroe E, et al. J Biol Chem, 2004 Jun 4. PMID 15067004
    5. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Ultanir SK, et al. Neuron, 2012 Mar 22. PMID 22445341, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cellular component organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 38-like
    NP_001076805.1
    XP_038964321.1
    XP_038964322.1
    XP_063142795.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083336.3 → NP_001076805.1  serine/threonine-protein kinase 38-like

      See identical proteins and their annotated locations for NP_001076805.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JT94, A4GW50, B1H211, D4AA09
      Related
      ENSRNOP00000002502.6, ENSRNOT00000002502.8
      Conserved Domains (1) summary
      cd05627
      Location:87 → 452
      STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      181346969..181423844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108393.2 → XP_038964321.1  serine/threonine-protein kinase 38-like isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT94, A4GW50, B1H211, D4AA09
      Conserved Domains (1) summary
      cd05627
      Location:87 → 452
      STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

    2. XM_039108394.2 → XP_038964322.1  serine/threonine-protein kinase 38-like isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT94, A4GW50, B1H211, D4AA09
      Conserved Domains (1) summary
      cd05627
      Location:87 → 452
      STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

    3. XM_063286725.1 → XP_063142795.1  serine/threonine-protein kinase 38-like isoform X1

      UniProtKB/TrEMBL
      A4GW50, B1H211, D4AA09
    Nucleotide Protein Strain
    Heading Accession and Version

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