PRSS2 serine protease 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRSS2provided by HGNC
Official Full Name: serine protease 2provided by HGNC
Primary source: HGNC:HGNC:9483
See related: Ensembl:ENSG00000275896 MIM:601564; AllianceGenome:HGNC:9483
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRY2; TRY8; TRYP2
Summary: This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
Orthologs: all
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Genomic context

Location:: 7q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (142770970..142774560)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (144116104..144130278)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7 (PATCHES)	NW_003571040.1 (974014..977604)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRSS2 regulates EMT and metastasis via MMP-9 in gastric cancer.
Title: PRSS2 regulates EMT and metastasis via MMP-9 in gastric cancer.
High expression of serine protease 2 (PRSS2) associated with invasion, metastasis, and proliferation in gastric cancer.
Title: High expression of serine protease 2 (PRSS2) associated with invasion, metastasis, and proliferation in gastric cancer.
Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression.
Title: Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression.
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.
Title: PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.
Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis.
Title: Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis.
TATI, TAT-2, and CRP as Prognostic Factors in Colorectal Cancer.
Title: TATI, TAT-2, and CRP as Prognostic Factors in Colorectal Cancer.
Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.
Title: Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.
Role of the Common PRSS1-PRSS2 Haplotype in Alcoholic and Non-Alcoholic Chronic Pancreatitis: Meta- and Re-Analyses.
Title: Role of the Common PRSS1-PRSS2 Haplotype in Alcoholic and Non-Alcoholic Chronic Pancreatitis: Meta- and Re-Analyses.
Data indicate association between polymorphism rs10273639 of the PRSS1-PRSS2 locus and pancreatitis development.
Title: Alcohol Consumption and Cigarette Smoking are Important Modifiers of the Association Between Acute Pancreatitis and the PRSS1-PRSS2 Locus in Men.
evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis
Title: Association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute and chronic pancreatitis: A case-control study from India.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hereditary pancreatitis MedGen: C0238339 OMIM: 167800 GeneReviews: PRSS1-Related Hereditary Pancreatitis, Pancreatitis Overview	Compare labs

EBI GWAS Catalog

Description
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120	PubMed
	env	Cleavage of HIV-1 gp120 with trypsin at residue 432 destroys CD4 binding	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487015

D7S2928 (e-PCR)
- UniSTS:47544

STS-X15505 (e-PCR)
- UniSTS:74448

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	TAS Traceable Author Statement more info
enables serine-type peptidase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral response	TAS Traceable Author Statement more info
involved_in collagen catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in collagen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen catabolic process	TAS Traceable Author Statement more info
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix disassembly	TAS Traceable Author Statement more info
involved_in positive regulation of cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell growth	TAS Traceable Author Statement more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in azurophil granule lumen	TAS Traceable Author Statement more info
located_in extracellular matrix	TAS Traceable Author Statement more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: trypsin-2

Names: anionic trypsinogen; protease serine 2 preproprotein; protease, serine 2; protease, serine, 2 (trypsin 2); trypsin II; trypsinogen 2

NP_001290343.1

EC 3.4.21.4

NP_002761.1

EC 3.4.21.4

XP_054214634.1

EC 3.4.21.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_001333.2

Range

624987..628610

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GenBank, FASTA, Sequence Viewer (Graphics)
NG_008322.2 RefSeqGene

Range

5028..8618

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001303414.2 → NP_001290343.1 trypsin-2 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001290343.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC245427, BC005814, BC030260, CA867206, DQ846873

Consensus CDS

CCDS83235.1

UniProtKB/TrEMBL

A6XMV8, A6XMV9, Q3SY20

Related

ENSP00000488437.1, ENST00000633969.1

Conserved Domains (2) summary

smart00020
Location:23 → 253

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:24 → 256

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_002770.4 → NP_002761.1 trypsin-2 isoform 2 preproprotein

See identical proteins and their annotated locations for NP_002761.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC245427, BC005814, BC030260, CA867206

Consensus CDS

CCDS83236.1

UniProtKB/Swiss-Prot

P07478

UniProtKB/TrEMBL

Q3SY20, Q5NV56

Related

ENSP00000488338.1, ENST00000539842.6

Conserved Domains (2) summary

smart00020
Location:23 → 239

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:24 → 242

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

NR_130149.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an internal exon and uses an alternate splice acceptor site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC245427, BC005814, BC030260, CA867206, CA951033

Related

ENST00000618750.2